Evidence map›Paper›PMID 33432480›Full record

ArticleVirchows Archiv : an international journal of pathology2021

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.

Arnaud de la Fouchardiere, Willeke Blokx, Léon C van Kempen, Boštjan Luzar, Sophie Piperno-Neumann, Susana Puig, Llucia Alos, Eduardo Calonje, Daniela Massi, ESP Dermatopathology Working Group and 2 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. [Immunohistochemistry of melanocytic tumours].Pathologie (Heidelberg, Germany) · 2026
    Review
  7. Article
  8. Cutaneous melanoma.Nature reviews. Disease primers · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Utility and Micro-Costing Framework forDiagnostics (Basel, Switzerland) · 2024
    Article
  14. Review
  15. Article
  16. Considerations on The Biologic Gray Zone of Melanocytic Tumors.Dermatology practical & conceptual · 2024
    Article
  17. An Atypical Presentation of BAP1-Inactivated Melanocytic Tumor.Dermatology practical & conceptual · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arnaud de la FouchardiereDepartment of Biopathology, Center Léon Bérard, Lyon, France.ORCID https://orcid.org/0000-0003-2251-8241
Willeke BlokxDepartment of Pathology, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-4647-8830
Léon C van KempenFaculty of Medical Sciences, University Medical Center Groningen, Department of Pathology & Medical Biology, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-0646-0705
Boštjan LuzarInstitute of Pathology, Medical Faculty University of Ljubljana, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0003-2534-8671
Sophie Piperno-NeumannDepartment of Medical Oncology, Institut Curie, 75005, Paris, France.
Susana PuigDepartment of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0003-1337-9745
Llucia AlosInstitut d'Investigació Biomèdica August Pi I Sunyer (IDIBAPS), Barcelona, Spain.ORCID https://orcid.org/0000-0002-3460-0384
Eduardo CalonjeDepartment of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. Jaime.calonje@kcl.ac.uk.ORCID http://orcid.org/0000-0001-7475-6423
Daniela MassiSection of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-5688-5923
ESP Dermatopathology Working Group
EORTC Melanoma Group
EURACAN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Intermediate lesions are most often the result of a clonal evolution within such nevi. Based on this established classification, we have suggested for each pathway a practical diagnostic approach, benefiting from the recently developed molecular tools, both in the setting of general pathology labs and expert centers. Moreover, recommendations regarding the re-excision and clinical follow-up are given to support decision-making in multidisciplinary tumor boards.

Indexed as

Cell ProliferationDecision Support TechniquesMolecular Diagnostic TechniquesAdultBiomarkers, TumorClinical Decision-MakingFemaleGenetic Predisposition to DiseaseHumansInfantMaleMelanocytesMelanomaMiddle AgedNeoplasm GradingNevus, PigmentedBiomarkers, TumorBAP-1 inactivated nevusDeep penetrating nevusIntermediate melanocytic tumorsMelanocytomaMelanoma variantsMELTUMPPigmented epithelioid melanocytomaSpitz tumors

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.