ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
The vessel density of the superficial retinal capillary plexus as a new biomarker in cerebral small vessel disease: an optical coherence tomography angiography study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Pooled it
- Retinal Optical Coherence Tomography-Angiography and Longitudinal Changes in Cognition and Cerebral Small Vessel Disease.Neurology · 2026Article
- Retinal hemodynamic and caliber biomarkers for the assessment of cerebral small vessel disease burden: insights from fundus fluorescein angiography.BMC neurology · 2026Article
- Biomarkers of Remote Ischaemic Conditioning in Stroke and Cerebral Small Vessel Disease: A Narrative Review.NeuroSci · 2026Review
- Ultra-widefield OCTA assessment of retinal and choroidal microcirculation in cerebral small vessel disease.Scientific reports · 2026Article
- Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers.Journal of the American College of Cardiology · 2026Review
- OCTA-Derived Retinal Biomarkers and Infarct Topography Improve Etiologic Classification of Recent Single Subcortical Infarction: A Nomogram Model.CNS neuroscience & therapeutics · 2026Article
- Associations between retinal microvasculature and cognition in middle-aged adults with type 1 diabetes without overt neurological symptoms.Cerebral circulation - cognition and behavior · 2026Article
- Associations between multimodal retinal measurements and cognitive functions in patients with cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- Unveiling potential retinal and choroidal markers with SS-OCTA in detecting cerebral small vessel disease.Scientific reports · 2025Article
- Macular vessel density is associated with cognitive function in preclinical p.R544C NOTCH3 mutation carriers.Journal of the Chinese Medical Association : JCMA · 2025Article
- Optical coherence tomography angiography in patients with focal epilepsy.Frontiers in neurology · 2025Article
- Retinal Microvasculature Changes Linked to Executive Function Impairment after COVID-19.Journal of clinical medicine · 2024Article
- OCTA: Essential or Gimmick?Ophthalmology and therapy · 2024Article
- Cerebral Small Vessel Disease in Population-Based Research: What are We Looking at - and What not?Aging and disease · 2024Article
- Insight into the Brain: Application of the Retinal Microvasculature as a Biomarker for Cerebrovascular Diseases through Optical Coherence Tomography Angiography.Current ophthalmology reports · 2024Article
- Macular vessel density in the superficial plexus is not a proxy of cerebrovascular damage in non-demented individuals: data from the NORFACE cohort.Alzheimer's research & therapy · 2024Article
- Peripapillary vessels density is closely related to cerebral white matter hyperintensities: An OCTA study.PloS one · 2024Article
- Retinal structure and vessel density changes in cerebral small vessel disease.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOptical coherence tomography angiography (OCTA) is a novel and noninvasive technique for the quantitative assessment of retinal microvascular perfusion. Since the retinal and cerebral small vessels share similar embryological origins, anatomical features, and physiological properties, altered retinal microvasculature might provide a new perspective on the mechanisms of cerebral small vessel disease (CSVD).
objectiveWe aimed to evaluate retinal vessel density (VD) in patients with CSVD using OCTA and identify associations with cerebral magnetic resonance imaging (MRI) markers and cognitive function.
methodsWe prospectively recruited 47 CSVD patients and 30 healthy controls (HCs) to participate in the study. All participants underwent OCTA to evaluate retinal microvascular perfusion. The VDs of the macular region in the superficial retinal capillary plexus (SRCP), deep retinal capillary plexus (DRCP), and foveal avascular zone (FAZ) were determined, along with the VD of the optic nerve head (ONH) in the radial peripapillary capillary (RPC) network. Additionally, cerebral MRI and cognitive function tests were performed.
resultsIn the macula area, the VD of the CSVD patients was significantly lower than HCs in the temporal quadrant of SRCP. In the ONH area, CSVD patients had lower VD than HCs in the peripapillary RPC network. According to multiple linear regression analysis, decreased VD of the macular SRCP was associated with white matter hyperintensity scores after adjustment for age, hypertension, diabetes, and hyperlipidemia. Furthermore, the VD of the macular SRCP was significantly correlated with CSVD patients' cognitive function, especially global cognition, memory function, attention function, information processing, and executive function.
conclusionOCTA revealed a significant decrease in retinal microvascular perfusion in CSVD patients, and retinal hypoperfusion was related to MRI markers and cognitive function, suggesting that these parameters could have potential utility as early disease biomarkers.
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