Evidence map›Paper›PMID 33432455›Full record

ArticleAmino acids2021

Colorimetric recognition of aromatic amino acid enantiomers by gluconic acid-capped gold nanoparticles.

Jiangxia Yang, Xiaoqi Li, Yingxiang Du, Mingxuan Ma, Liu Zhang, Jian Zhang, Peipei Li

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiangxia YangKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
Xiaoqi LiAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, People's Republic of China. xiaoqili8619@163.com.
Yingxiang DuKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China. du_yingxiang@126.com.ORCID http://orcid.org/0000-0001-6747-5607
Mingxuan MaKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
Liu ZhangKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
Jian ZhangKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
Peipei LiKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
China Pharmaceutical University · CNNanjing University of Chinese Medicine · CN

Funding

Natural Science Foundation of Jiangsu Province No.: BK20141353
6 · The paper itself

Abstract

In this work, we prepared gold nanoparticles (AuNPs) by employing gluconic acid (GlcA) as reducing-cum-stabilizing agent. The proposed GlcA-AuNPs successfully worked as a colorimetric sensor for visual chiral recognition of aromatic amino acid enantiomers, namely tyrosine (D/L-Tyr), phenylalanine (D/L-Phe), and tryptophan (D/L-Trp). After adding L-types to GlcA-AuNPs solution, the color of the mixture changed from red to purple (or gray), while no obvious color change occurred on the addition of D-types. The effect can be detected by naked eyes. The particles have been characterized by transmission electron microscopy, Fourier-transform infrared spectroscopy, zeta potential, the dynamic light scattering analysis as well as UV-Vis spectroscopy. This assay can be used to determine the enantiomeric excess of L-Trp in the range from 0 to + 100%. The method has advantages in simplicity, sensitivity, fast response, and low cost.

Indexed as

ColorimetryGluconatesGoldMetal NanoparticlesPhenylalanineStereoisomerismTryptophanTyrosineGluconatesgluconic acidGoldPhenylalanineTryptophanTyrosineAromatic amino acidsChiral recognitionColorimetric analysisGold nanoparticles

Identifiers

PMID33432455
OpenAlexW3120199134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.