ArticleEnvironmental science and pollution research international2021
Antidiabetic and antioxidant activity of phlorotannins extracted from the brown seaweed Cystoseira compressa in streptozotocin-induced diabetic rats.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Review
- Brown Seaweeds and Their Bioactive Compounds in Type 2 Diabetes: Mechanisms Underlying Metabolic Regulation.International journal of molecular sciences · 2026Review
- Seaweed bioactives: A comprehensive review of their nutritional, medicinal, and functional roles.iScience · 2026Review
- Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats.Animal models and experimental medicine · 2025Article
- Multi-active phlorotannins boost antimicrobial peptide LL-37 to promote periodontal tissue regeneration in diabetic periodontitis.Materials today. Bio · 2025Article
- Article
- Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.Nutrients · 2025Review
- Improvement of Alginate Extraction from Brown Seaweed (Marine drugs · 2024Article
- The Ocean's Pharmacy: Health Discoveries in Marine Algae.Molecules (Basel, Switzerland) · 2024Review
- New insights into the anticancer effects ofFrontiers in pharmacology · 2024Article
- Polyherbal extract improves glycometabolic control in alloxan-induced diabetic ratsIranian journal of basic medical sciences · 2024Article
- Modulation Effects ofFoods (Basel, Switzerland) · 2023Article
- Rehashing Our Insight of Seaweeds as a Potential Source of Foods, Nutraceuticals, and Pharmaceuticals.Foods (Basel, Switzerland) · 2023Review
- Effect of Ishophloroglucin A Isolated fromMarine drugs · 2023Article
- Roles of Marine Macroalgae or Seaweeds and Their Bioactive Compounds in Combating Overweight, Obesity and Diabetes: A Comprehensive Review.Marine drugs · 2023Review
- Trifuhalol A, a phlorotannin from the brown algaeCurrent research in food science · 2023Article
- Seaweed for climate mitigation, wastewater treatment, bioenergy, bioplastic, biochar, food, pharmaceuticals, and cosmetics: a review.Environmental chemistry letters · 2023Review
- Fillet Fish Fortified with Algal Extracts ofMarine drugs · 2022Article
- Overview of Phlorotannins' Constituents in Fucales.Marine drugs · 2022Review
- A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins.Marine drugs · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is considered a set of diseases that lead to high glucose level due to the absolute or relative absence of insulin. The study investigated the antioxidant activity and antidiabetic effect of phlorotannins extracted from brown seaweed Cystoseira compressa. Phlorotannins were extracted from C. compressa. It was confirmed by 2,4 dimethoxy benzaldehyde assay (DMBA), ultraviolet spectra, Fourier transform infrared spectroscopy, and ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The free radical scavenging activity of phlorotannins was estimated by total antioxidant capacity, 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity, and 2,2 azino-bis3-ethylbenthiazoline-6-sulfonic acid assays. Four groups of albino rats used in this study include control normal, control phlorotannins extract, diabetic by intraperitoneally administering of streptozotocin, and diabetic treatment with 60 mg/kg of phlorotannin extract after 4 weeks of diabetes induction. The main compound identified by UPLC-MS/MS in C. compressa extract belonged to the fuhalol. C. compressa extract showed high antioxidant properties. Phlorotannins significantly decreased serum glucose, liver malondialdehyde, and α-amylase, glucosidase activities. However, total antioxidant capacity, serum insulin, hepatic glutathione, and AMPKα2 expression in skeletal muscle were improved compared to the diabetic group. The histopathological examination showed that phlorotannins markedly reduced damage in β cells of pancreases. Phlorotannins from C. compressa have efficient antioxidant activity and the antidiabetic effect that may be utilized in human health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.