ArticleEJNMMI physics2021
Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model.
Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Targeted Alpha Therapy as a Multiscale Design Problem: From Radioactive Decay to Therapeutic Outcome.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Comparative dosimetry study of PARaDIM and RT-PHITS with ICRP publication 128: calculation of organ doses fromRadiological physics and technology · 2026Article
- Monte Carlo microdosimetry ofEJNMMI physics · 2026Article
- Impact of simulation settings, time-activity curve integration range, and imaging time points on full Monte Carlo-basedAnnals of nuclear medicine · 2026Article
- Improved organ absorbed dose estimation in abdominal CT using DICOM header-based tube current modulation profiles: Validation with measurements and Monte Carlo simulations.Journal of applied clinical medical physics · 2025Article
- Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach.Medical physics · 2025Article
- Monte Carlo-calculated perturbation correction factors in clinical proton beams using PHITS.Technical innovations & patient support in radiation oncology · 2025Article
- Evaluation of relative biological effectiveness ofEJNMMI physics · 2025Article
- Feasibility of individual dosimetry using RT-PHITS for patients with SPECT/CT imaging afterPhysical and engineering sciences in medicine · 2025Article
- Establishment of a practical methodology for evaluating equieffective dose of individual patients based on RT-PHITS.EJNMMI physics · 2025Article
- In vitro and in silico study of biological effects on cancer cells in the presence of metallic materials during radiotherapy.Journal of radiation research · 2024Article
- Investigation of ionization chamber perturbation factors using proton beam and Fano cavity test for the Monte Carlo simulation code PHITS.Radiological physics and technology · 2024Article
- A machine learning-based model for a dose point kernel calculation.EJNMMI physics · 2023Article
- Review
- A Machine Learning based model for a Dose Point Kernel calculation.Research square · 2023Article
- Quantitative SPECT/CT imaging of lead-212: a phantom study.EJNMMI physics · 2022Article
- Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy.EJNMMI physics · 2021Article
- Medical application of particle and heavy ion transport code system PHITS.Radiological physics and technology · 2021Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAn individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose of this study was to develop a system for calculating not only absorbed doses but also EQDX(α/β) from the PET-CT images of patients for targeted alpha therapy (TAT), considering the dose dependence of the relative biological effectiveness, the dose-rate effect, and the dose heterogeneity.
methodsA general-purpose Monte Carlo particle transport code PHITS was employed as the dose calculation engine in the system, while the microdosimetric kinetic model was used for converting the absorbed dose to EQDX(α/β). PHITS input files for describing the geometry and source distribution of a patient are automatically created from PET-CT images, using newly developed modules of the radiotherapy package based on PHITS (RT-PHITS). We examined the performance of the system by calculating several organ doses using the PET-CT images of four healthy volunteers after injecting
resultsThe deposition energy map obtained from our system seems to be a blurred image of the corresponding PET data because annihilation γ-rays deposit their energies rather far from the source location. The calculated organ doses agree with the corresponding data obtained from OLINDA 2.0 within 20%, indicating the reliability of our developed system. Test calculations by replacing the labeled radionuclide from
conclusionsAs an extension of RT-PHITS, an individual dosimetry system for nuclear medicine was developed based on PHITS coupled with the microdosimetric kinetic model. It enables us to predict the therapeutic and side effects of TAT based on the clinical data largely available from conventional external radiotherapy.
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