ArticleNature protocols2021
Reaction screening in multiwell plates: high-throughput optimization of a Buchwald-Hartwig amination.
Article in Nature protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- High-throughput reaction screening using acoustic ejection mass spectrometry.Nature protocols · 2026Review
- Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- High-throughput solid microsampling through stochastic robotic automation.Communications chemistry · 2026Article
- Mapping Regioisomer-Dependent Buchwald-Hartwig C-N Coupling: Bromoimidazo[1,5-a]pyridines as a Model Electrophile Series.Molecules (Basel, Switzerland) · 2026Article
- Encapsulated droplet array for intensified micromole-scale high-throughput reaction screening.Nature communications · 2026Article
- Advances in NiACS catalysis · 2026Review
- Local reaction condition optimization via machine learning.Journal of molecular modeling · 2025Review
- Simple User-Friendly Reaction Format.Molecular informatics · 2025Article
- An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.Angewandte Chemie (International ed. in English) · 2024Article
- Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients.Chemical science · 2024Article
- Incorporating Synthetic Accessibility in Drug Design: Predicting Reaction Yields of Suzuki Cross-Couplings by Leveraging AbbVie's 15-Year Parallel Library Data Set.Journal of the American Chemical Society · 2024Article
- Parallel multi-droplet platform for reaction kinetics and optimization.Chemical science · 2023Article
- A deep learning framework for accurate reaction prediction and its application on high-throughput experimentation data.Journal of cheminformatics · 2023Article
- High-Throughput Diversification of Complex Bioactive Molecules by Accelerated Synthesis in Microdroplets.Angewandte Chemie (International ed. in English) · 2023Article
- A Brief Introduction to Chemical Reaction Optimization.Chemical reviews · 2023Review
- Pd-Catalyzed Cross-Couplings: On the Importance of the Catalyst Quantity Descriptors, mol % and ppm.Organic process research & development · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Chemical space is vast, and chemical reactions involve the complex interplay of multiple variables. As a consequence, reactions can fail for subtle reasons, necessitating screening of conditions. High-throughput experimentation (HTE) techniques enable a more comprehensive array of data to be obtained in a relatively short amount of time. Although HTE can be most efficiently achieved with automated robotic dispensing equipment, the benefits of running reaction microarrays can be accessed in any regularly equipped laboratory using inexpensive consumables. Herein, we present a cost-efficient approach to HTE, examining a Buchwald-Hartwig amination as our model reaction. Experiments are carried out in a machined aluminum 96-well plate, taking advantage of solid transfer scoops and pipettes to facilitate rapid reagent transfer. Reaction vials are simultaneously heated and mixed, using a magnetic stirrer, and worked up in parallel, using a plastic filter plate. Analysis by gas chromatography provides the chemist with 96 data points with minimal commitment of time and resources. The best-performing experiment can be selected for scale-up and isolation, or the data can be used for designing future optimization experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.