Evidence map›Paper›PMID 33432154›Full record

ArticleNature microbiology2021

Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.

Joana Faria, Vanessa Luzak, Laura S M Müller, Benedikt G Brink, Sebastian Hutchinson, Lucy Glover, David Horn, T Nicolai Siegel

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 79 citations in OpenAlex.

  1. Microbiology spectrum · 2026
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  2. Article
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  4. A factor integrating transcription and repression of surface antigen genes in African trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  8. Review
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  10. Hidden origami inmBio · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Joana Faria *Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0001-6274-8143
Vanessa Luzak *Department of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany.
Laura S M MüllerDepartment of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID http://orcid.org/0000-0001-7912-7271
Benedikt G BrinkDepartment of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-2291-8870
Sebastian HutchinsonWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0003-3895-0282
Lucy GloverWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0001-7191-6890
David HornWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK. d.horn@dundee.ac.uk.ORCID http://orcid.org/0000-0001-5173-9284
T Nicolai SiegelDepartment of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany. n.siegel@lmu.de.ORCID http://orcid.org/0000-0002-1715-7907
Ludwig-Maximilians-Universität München · DEUniversity of Dundee · GBInserm · FRInstitut Pasteur · FR

Funding

European Research Council 715466Medical Research Council MR/K015869/1Wellcome Trust 100320Wellcome Trust 203134/Z/16/Z
6 · The paper itself

Abstract

Highly selective gene expression is a key requirement for antigenic variation in several pathogens, allowing evasion of host immune responses and maintenance of persistent infections

Indexed as

Antigenic VariationChromosomesGene Expression RegulationGenome, ProtozoanMultigene FamilyRNA, Spliced LeaderRNA SplicingTranscription, GeneticTrypanosoma brucei bruceiVariant Surface Glycoproteins, TrypanosomaRNA, Spliced LeaderVariant Surface Glycoproteins, Trypanosoma

Identifiers

PMID33432154
PMCPMC7610597
OpenAlexW3119864639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.