ArticleNature microbiology2021
Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice.
Abstract read
In one paragraph
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 3 pooled it
17.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
198 citing papers in PubMed, 3 syntheses or guidelines pooled it, 301 citations in OpenAlex.
- Gut microbes and immunotherapy for non-small cell lung cancer: a systematic review.Frontiers in oncology · 2025Pooled it
- Checkpoint inhibitor responses can be regulated by the gut microbiota - A systematic review.Neoplasia (New York, N.Y.) · 2023Pooled it
- The correlation between probiotic use and outcomes of cancer patients treated with immune checkpoint inhibitors.Frontiers in pharmacology · 2022Pooled it
- Trial
- Microbiota as a modulator of drug response: targeting microbial-drug crosstalk in cancer therapy.Gut microbes · 2026Review
- Article
- The impact of gut microbiota and metabolite-driven immune cell spatiotemporal dynamics on tumors.Gut microbes · 2026Review
- Engineered bacteria in disease diagnosis and therapy: A synthetic biology perspective.Synthetic and systems biotechnology · 2026Review
- Gut microbiota associate with disease severity and survival in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026Article
- What is in the Dust? Species-Level Profiling Reveals Pathogenic and Protective Potential of Microbial Communities in Daycare and Home Environments.Environmental microbiology reports · 2026Article
- The role of gut microbiota in thyroid cancer: from pathogenesis to diagnosis and treatment.Journal of endocrinological investigation · 2026Review
- Association between antibiotic exposure and outcomes of chemoimmunotherapy in extensive-stage small cell lung cancer: a single-center retrospective cohort study.Translational lung cancer research · 2026Article
- Gut microbiota modulation of systemic immunity and cancer immunotherapy: mechanisms, evidence, and therapeutic implications.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Review
- Harnessing the microbiome: a new frontier in lung cancer immunotherapy.Cancer biology & medicine · 2026Review
- Probiotics unveiled: bridging general health benefits to the era of precision medicine.World journal of microbiology & biotechnology · 2026Review
- The effects of probiotics duration and type on immunotherapy efficacy in non-small cell lung cancer with or without antibiotics.Journal of translational medicine · 2026Article
- Toward a Dual-Axis Model of Microbiome Modulation in Cancer Immunotherapy: Pathobiont Elimination and Functional Ecosystem Restoration.Cellular and molecular bioengineering · 2026Article
- In Situ Biosynthesis of Pd Nanocrystals in Bifidobacterium Bioreactor as Dual Immune Stimulators for Immuno-Chemodynamic Therapy of Cold Tumor.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Can Complex 3D Models Effectively Replace 2D and Animal Models to Investigate the Microbe-Tumor-Immune Axis in Pancreatic Cancer Studies?Nutrients · 2026Review
- Leveraging gut microbiota for enhanced immune checkpoint blockade in solid tumor therapy.Chinese medical journal · 2026Review
138 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 10 institutions in 3 countries.
Se-Hoon Lee *Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sung-Yup Cho *Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Youngmin Yoon *Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
Changho Park *Genome and Company, Gyeonggi-do, Korea.
Jinyoung SohnGenome and Company, Gyeonggi-do, Korea.
Jin-Ju JeongGenome and Company, Gyeonggi-do, Korea.
Bu-Nam JeonGenome and Company, Gyeonggi-do, Korea.
Mongjoo JangGenome and Company, Gyeonggi-do, Korea.
Choa AnGenome and Company, Gyeonggi-do, Korea.
Suro LeeGenome and Company, Gyeonggi-do, Korea.
Yun Yeon KimGenome and Company, Gyeonggi-do, Korea.
Gihyeon KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
Sujeong KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
Yunjae KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
Gwang Bin LeeDepartment of Chemistry, Yonsei University, Seoul, Korea.
Eun Ju LeeGenome and Company, Gyeonggi-do, Korea.
Sang Gyun KimGenome and Company, Gyeonggi-do, Korea.
Hong Sook KimDivision of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yeongmin KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
Hyun KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
Hyun-Suk YangDepartment of Biotechnology, Hoseo University, Asan, Korea.
Sarang KimDepartment of Biotechnology, Hoseo University, Asan, Korea.
Seonggon KimLaboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Korea.
Hayung ChungKorea Basic Science Institute, Seoul Center, Seoul, Korea.
Myeong Hee MoonDepartment of Chemistry, Yonsei University, Seoul, Korea.ORCID http://orcid.org/0000-0002-5454-2601
Myung Hee NamKorea Basic Science Institute, Seoul Center, Seoul, Korea.
Jee Young KwonThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Sungho WonDepartment of Public Health Sciences, Seoul National University, Seoul, Korea.
Joon-Suk Park *Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Korea.
George M Weinstock *The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-2997-4592
Charles Lee *The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Kyoung Wan YoonGenome and Company, Gyeonggi-do, Korea. kwyoon8@gmail.com.
Hansoo ParkDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea. hspark27@gist.ac.kr.ORCID http://orcid.org/0000-0003-1027-8850
Genome and Company (South Korea) · KRGwangju Institute of Science and Technology · KRHoseo University · KRSamsung Medical Center · KRJackson Laboratory · USKorea Basic Science Institute · KRSeoul National University · KRYonsei University · KRDaegu-Gyeongbuk Medical Innovation Foundation · KREwha Womans University · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome can influence the development of tumours and the efficacy of cancer therapeutics
Indexed as
AnimalsBifidobacterium bifidumCarcinoma, Non-Small-Cell LungDrug Therapy, CombinationGastrointestinal MicrobiomeHumansImmune Checkpoint InhibitorsInterferon-gammaLung NeoplasmsMetabolomeMiceNeoplasms, ExperimentalProbioticsSpecies SpecificityTranscriptomeTryptophanImmune Checkpoint InhibitorsInterferon-gammaTryptophan
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.