Evidence map›Paper›PMID 33432140›Full record

ArticleNature materials2021

Living materials with programmable functionalities grown from engineered microbial co-cultures.

Charlie Gilbert, Tzu-Chieh Tang, Wolfgang Ott, Brandon A Dorr, William M Shaw, George L Sun, Timothy K Lu, Tom Ellis

Abstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 331 citations in OpenAlex.

  1. Article
  2. Review
  3. De Novo Autogenic Engineered Living Functional Materials.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
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  13. Article
  14. Article
  15. Article
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  17. Article
  18. Review
  19. Artificial Symbiosis for Bulk Production of Bacterial Cellulose Composites.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Charlie Gilbert *Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6231-9584
Tzu-Chieh Tang *Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6215-8714
Wolfgang OttImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Brandon A DorrSynthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.
William M ShawImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
George L SunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Timothy K LuSynthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA. timlu@mit.edu.ORCID http://orcid.org/0000-0002-3918-8923
Tom EllisImperial College Centre for Synthetic Biology, Imperial College London, London, UK. t.ellis@imperial.ac.uk.ORCID http://orcid.org/0000-0001-5392-976X
Imperial College London · GBMassachusetts Institute of Technology · USMediaTek (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological systems assemble living materials that are autonomously patterned, can self-repair and can sense and respond to their environment. The field of engineered living materials aims to create novel materials with properties similar to those of natural biomaterials using genetically engineered organisms. Here, we describe an approach to fabricating functional bacterial cellulose-based living materials using a stable co-culture of Saccharomyces cerevisiae yeast and bacterial cellulose-producing Komagataeibacter rhaeticus bacteria. Yeast strains can be engineered to secrete enzymes into bacterial cellulose, generating autonomously grown catalytic materials and enabling DNA-encoded modification of bacterial cellulose bulk properties. Alternatively, engineered yeast can be incorporated within the growing cellulose matrix, creating living materials that can sense and respond to chemical and optical stimuli. This symbiotic culture of bacteria and yeast is a flexible platform for the production of bacterial cellulose-based engineered living materials with potential applications in biosensing and biocatalysis.

Indexed as

AcetobacteraceaeCelluloseCoculture TechniquesSaccharomyces cerevisiaeCellulose

Identifiers

PMID33432140
OpenAlexW3120402208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.