ArticleScientific reports2021
Decreasing auditory input induces neurogenesis impairment in the hippocampus.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Conductive Hearing Loss is Associated With Dementia in the All of Us Research Program.The Laryngoscope · 2026Article
- Hearing Loss, Cognitive Decline, and Dementia: Clinical Intersections.Audiology research · 2026Review
- Structural and Functional Brain Alterations Induced by Noise Exposure: A Comprehensive Review.NeuroSci · 2026Review
- Network Meta-Analysis of Cognitive Impairment and miRNA Expression in Alzheimer's Disease Patients with Hearing Loss: A Systematic Review and Cross-Validation.Journal of clinical medicine · 2026Review
- TRPV4 mediates aminoglycoside trafficking and ototoxicity without compromising antimicrobial efficacy.Cell death discovery · 2026Article
- Differences of Gradient Connectivity and Ventricle Volumes in Long-Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures.Human brain mapping · 2026Article
- m6A RNA methylation in neural plasticity, brain aging, and neurodegenerative vulnerability.Molecular brain · 2026Review
- DNAH11 impairs memory via disrupted synaptic plasticity in noise-induced hidden hearing loss mice.Cell biology and toxicology · 2025Article
- Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats.Scientific reports · 2025Article
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Beyond the auditory system: cognitive implications of age-related hearing loss.Frontiers in aging neuroscience · 2025Review
- Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.Alzheimer's research & therapy · 2024Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- Transcriptomic analysis reveals prolonged neurodegeneration in the hippocampus of adult C57BL/6N mouse deafened by noise.Frontiers in neuroscience · 2024Article
- The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration.Journal of personalized medicine · 2023Review
- Redox Imbalance as a Common Pathogenic Factor Linking Hearing Loss and Cognitive Decline.Antioxidants (Basel, Switzerland) · 2023Review
- Hearing loss and its link to cognitive impairment and dementia.Frontiers in dementia · 2023Review
- Hippocampal atrophy is associated with hearing loss in cognitively normal adults.Frontiers in neuroscience · 2023Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related to hearing loss in the hippocampus remains unknown. Using a conductive hearing loss (CHL) model, we investigated whether a decrease in sound level could induce impairment of hippocampal neurogenesis and examined the differences between unilateral CHL (uCHL) and bilateral CHL (bCHL). To establish the CHL mouse model, ears were unilaterally or bilaterally occluded for five weeks by auditory canal ligation. Although hearing thresholds were significantly increased following CHL, CHL mice exhibited no significant loss of spiral ganglion or hippocampal neurons. Hippocampal neurogenesis was significantly and equally decreased in both sides following uCHL. More severe decreases in hippocampal neurogenesis were observed in both sides in bCHL mice compared with that in uCHL mice. Furthermore, microglial invasion significantly increased following CHL. Serum cortisol levels, which indicate stress response, significantly increased following bCHL. Therefore, auditory deprivation could lead to increased microglial invasion and stress responses and might be a risk factor for hippocampal neurogenesis impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.