ArticleScientific reports2021
Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008-2011.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations between the triglyceride‒glucose index and the odds of low muscle mass and sarcopenia: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Pooled it
- Article
- Association of frailty index with sarcopenia: Mediation analysis of triglyceride-glucose-related indices: a cross-sectional study.Medicine · 2026Article
- Association of Triglyceride-Glucose Index and Its Related Parameters With Handgrip Strength Asymmetry.Journal of cachexia, sarcopenia and muscle · 2026Article
- Association between the triglyceride-glucose-frailty index and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of the poverty-income ratio.Cardiovascular diabetology · 2026Article
- Prospective association between the triglyceride-glucose index and frailty in middle-aged and older adults: insights from a nationwide cohort study.European journal of medical research · 2026Article
- Association between triglyceride-glucose index and sarcopenia in older adults without either dysglycemia or central obesity: a cross-sectional study from CHARLS.Open medicine (Warsaw, Poland) · 2026Article
- The TyG Index and Obesity Indicators Predicting Low Muscle Mass in US Adults Without Diabetes: NHANES 2011-2018.Journal of nutrition and metabolism · 2026Article
- Vitamin D sufficiency and its relationship with muscle health across the menopausal transition and aging: Finnish cohorts of middle-aged women and older women and men.European journal of clinical nutrition · 2025Article
- Associations of the Neutrophil-to-Lymphocyte Ratio(NLR), Triglyceride-Glucose Index (TyG), and TyG-derived indices with vitality decline in older adults in China: a study within the Integrated Care for Older People (ICOPE) framework.Lipids in health and disease · 2025Article
- More comprehensive relationship between eGDR and sarcopenia in China: a nationwide cohort study with national representation.Diabetology & metabolic syndrome · 2025Article
- Association of triglyceride-glucose index and its combinations with sarcopenia among community-dwelling older adults: based on the Chongqing Aging and Sarcopenia Evaluation (CHASE) cohort.Frontiers in physiology · 2025Article
- Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study.Frontiers in aging neuroscience · 2025Article
- Associations between different triglyceride glucose index-related obesity indices and sarcopenia: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Relationship Between Triglyceride-Glucose Index and Handgrip Strength in the Midlife and Elderly Population: Evidence From a Chinese Cohort.International journal of endocrinology · 2025Article
- Causal relationship between lipid profile and muscle atrophy: A bi-directional Mendelian randomization study.Animal models and experimental medicine · 2025Article
- Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025Review
- Factors associated with skeletal muscle mass in middle-aged men living with HIV.Journal of cachexia, sarcopenia and muscle · 2024Article
- Muscle Mass Adjusted by Body Height is not Correlated with Mobility of Middle-Aged and Older Adults.Current developments in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 years from the Korea National Health and Nutrition Examination Survey between 2008 and 2011. The TyG index was calculated as ln[triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Dual-energy X-ray absorptiometry was used to measure appendicular lean mass (ALM). Low muscle mass was defined an ALM/weight of 2 standard deviations (SD) below of young participants. The overall prevalence of low muscle mass was 4.7%. The prevalence of low muscle mass increased linearly with the quartiles of the TyG index, 2.5%, 4.2%, 5.6%, and 6.7% in Q1-Q4, respectively. The TyG index was negatively associated with ALM/weight both in men (r = - 0.302) and women (r = - 0.230). The odds ratio (OR) for low muscle mass was 2.08 in the highest quartile compared to the lowest quartile. High TyG index was associated with an increased risk of low muscle mass (OR for 1SD increase: 1.13). Increased TyG index was associated with the risk of low muscle mass independent of confounding factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.