Evidence map›Paper›PMID 33432034›Full record

ArticleScientific reports2021

Defining a therapeutic range for regeneration of ischemic myocardium via shock waves.

Leo Pölzl, Felix Nägele, Jakob Hirsch, Michael Graber, Daniela Lobenwein, Elke Kirchmair, Rosalie Huber, Christian Dorfmüller, Sophia Lechner, Georg Schäfer and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Leo PölzlDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Felix NägeleDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Jakob HirschDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Michael GraberDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Daniela LobenweinDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Elke KirchmairDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Rosalie HuberDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Christian DorfmüllerHeart Regeneration Technologies GmbH, Innsbruck, Austria.
Sophia LechnerDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Georg SchäferDepartment of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Martin HermannDepartment of Anesthesiology, Medical University of Innsbruck, Innsbruck, Austria.
Helga FritschInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck, Innsbruck, Austria.
Ivan TancevskiDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Michael GrimmDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Johannes HolfeldDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Can Gollmann-TepeköylüDepartment of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria. can.tepekoeylue@i-med.ac.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeutic range for shock wave application for myocardial regeneration. We could demonstrate that SWT does not induce cellular damage beneath energy levels of 0.27 mJ/mm

Indexed as

AnimalsCells, CulturedDose-Response Relationship, RadiationExtracorporeal Shockwave TherapyHeartHigh-Energy Shock WavesHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMyocardial IschemiaMyocardiumRadiation DosageRegeneration

Identifiers

PMID33432034
PMCPMC7801389

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.