Evidence map›Paper›PMID 33432003›Full record

ArticleScientific reports2021

Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland.

Janice L Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P Bouchie, Brigid Bleaken, A Sue Menko, Maria A Kukuruzinska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Janice L WalkerDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 564, Philadelphia, PA, 19107, USA.
Weihao WangDepartment of Translational Dental Medicine, School of Dental Medicine, Boston University, 700 Albany Street, W201, Boston, MA, 02118, USA.
Edith LinDepartment of Translational Dental Medicine, School of Dental Medicine, Boston University, 700 Albany Street, W201, Boston, MA, 02118, USA.
Alison RomisherDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 564, Philadelphia, PA, 19107, USA.
Meghan P BouchieDepartment of Translational Dental Medicine, School of Dental Medicine, Boston University, 700 Albany Street, W201, Boston, MA, 02118, USA.
Brigid BleakenDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 564, Philadelphia, PA, 19107, USA.
A Sue MenkoDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 564, Philadelphia, PA, 19107, USA. sue.menko@jefferson.edu.
Maria A KukuruzinskaDepartment of Translational Dental Medicine, School of Dental Medicine, Boston University, 700 Albany Street, W201, Boston, MA, 02118, USA. mkukuruz@bu.edu.
Boston University · USThomas Jefferson University · US

Funding

Regulation of SMG Development by Adhesion ReceptorsR01DE014437 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KUKURUZINSKA, MARIA A., MENKO, A. SUE · 2002 to 2012
$2.6M
NIDCR NIH HHS R01 DE014437
6 · The paper itself

Abstract

The development of ductal structures during branching morphogenesis relies on signals that specify ductal progenitors to set up a pattern for the ductal network. Here, we identify cellular asymmetries defined by the F-actin cytoskeleton and the cell adhesion protein ZO-1 as the earliest determinants of duct specification in the embryonic submandibular gland (SMG). Apical polarity protein aPKCζ is then recruited to the sites of asymmetry in a ZO-1-dependent manner and collaborates with ROCK signaling to set up apical-basal polarity of ductal progenitors and further define the path of duct specification. Moreover, the motor protein myosin IIB, a mediator of mechanical force transmission along actin filaments, becomes localized to vertices linking the apical domains of multiple ductal epithelial cells during the formation of ductal lumens and drives duct maturation. These studies identify cytoskeletal, junctional and polarity proteins as the early determinants of duct specification and the patterning of a ductal tree during branching morphogenesis of the SMG.

Indexed as

MorphogenesisActinsAnimalsCell AdhesionMiceProtein Kinase CProtein Kinase C zetarho-Associated KinasesSubmandibular GlandZonula Occludens-1 ProteinActinsProtein Kinase CProtein Kinase C zetarho-Associated KinasesTjp1 protein, mouseZonula Occludens-1 Protein

Identifiers

PMID33432003
PMCPMC7801450
OpenAlexW3120399659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.