ArticleScientific reports2021
Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Resting-state functional connectivity alterations in dementia with Lewy bodies: a systematic review and activation likelihood estimation meta-analysis.Brain imaging and behavior · 2026Pooled it
- Prosodic recitation training selectively enhances sensorimotor connectivity during poetry reading: a longitudinal fNIRS study.Communications biology · 2026Article
- Cortical structural variations and scoliosis risk: insights from a large-scale Mendelian randomization analysis.Brain & spine · 2026Article
- Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers.Discover oncology · 2025Article
- Frequency-Dependent Changes in Wavelet-ALFF in Patients With Acute Basal Ganglia Ischemic Stroke: A Resting-State fMRI Study.Neural plasticity · 2025Article
- Neural signal analysis in chronic stroke: advancing intracortical brain-computer interface design.Frontiers in human neuroscience · 2025Article
- Mapping the computational similarity of individual neurons within large-scale ensemble recordings using the SIMNETS analysis framework.Frontiers in neuroscience · 2025Article
- Stimulation of caudal inferior and middle frontal gyri disrupts planning during spoken interaction.Current biology : CB · 2024Article
- Associations between mother's depressive symptoms during pregnancy and newborn's brain functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Unlocking the musical brain: A proof-of-concept study on playing the piano in MRI scanner with naturalistic stimuli.Heliyon · 2023Article
- Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination.Translational psychiatry · 2022Article
- Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.Nature communications · 2022Article
- Article
- Neuroprosthetics in systems neuroscience and medicine.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Intracortical brain-computer interfaces (iBCIs) allow people with paralysis to directly control assistive devices using neural activity associated with the intent to move. Realizing the full potential of iBCIs critically depends on continued progress in understanding how different cortical areas contribute to movement control. Here we present the first comparison between neuronal ensemble recordings from the left middle frontal gyrus (MFG) and precentral gyrus (PCG) of a person with tetraplegia using an iBCI. As expected, PCG was more engaged in selecting and generating intended movements than in earlier perceptual stages of action planning. By contrast, MFG displayed movement-related information during the sensorimotor processing steps preceding the appearance of the action plan in PCG, but only when the actions were instructed using auditory cues. These results describe a previously unreported function for neurons in the human left MFG in auditory processing contributing to motor control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.