Evidence map›Paper›PMID 33431967›Full record

ArticleScientific reports2021

Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes.

Keimon Sayama, Katsuyuki Yuki, Keiichi Sugata, Satoko Fukagawa, Tetsuji Yamamoto, Shigaku Ikeda, Takatoshi Murase

Open access · goldAbstract readControlled Clinical Trial
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Synergistic COInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Recent advances in acid sensing by G protein coupled receptors.Pflugers Archiv : European journal of physiology · 2024
    Review
  7. Physiological relevance of proton-activated GPCRs.Pflugers Archiv : European journal of physiology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Keimon SayamaBiological Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
Katsuyuki YukiBiological Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
Keiichi SugataBiological Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
Satoko FukagawaBiological Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
Tetsuji YamamotoBiological Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.
Shigaku IkedaDepartment of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Takatoshi MuraseBiological Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan. murase.takatoshi@kao.com.
Kao Corporation (Japan) · JPJuntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon dioxide (CO

Indexed as

KeratinocytesAdultCarbon DioxideCells, CulturedCytoprotectionDouble-Blind MethodHumansInfant, NewbornInflammationMaleMiddle AgedPlacebosRadiation InjuriesRadiation-Protective AgentsReceptors, G-Protein-CoupledSignal TransductionCarbon DioxideGPR65 protein, humanPlacebosRadiation-Protective AgentsReceptors, G-Protein-Coupled

Identifiers

PMID33431967
PMCPMC7801444
OpenAlexW3119523567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.