ArticleScientific reports2021
State-dependent bioelectronic interface to control bladder function.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Effect of Transcutaneous Acupoint Electrical Stimulation on Urinary Retention and Urinary ATP in Elderly Patients After Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial.Clinical interventions in aging · 2022Trial
- Influence of Sacral and Thoracolumbar Spinal Nerve Electrical Stimulation on Colonic Motility in Anesthetized Yucatan Male Pigs.Neurogastroenterology and motility · 2026Article
- Recent advances in facilitating the translation of bioelectronic medicine therapies.Current opinion in biomedical engineering · 2025Article
- Impaired inhibitory reno-renal reflex responses in chronic kidney disease.Frontiers in physiology · 2025Article
- The inhibitory effect of intraspinal microstimulation of the sacral spinal cord on nonlinear bladder reflex dynamics in cats.Frontiers in neuroscience · 2025Article
- Swine Pudendal Nerve as a Model for Neuromodulation Studies to Restore Lower Urinary Tract Dysfunction.International journal of molecular sciences · 2024Article
- Pathways and parameters of sacral neuromodulation in rats.American journal of physiology. Renal physiology · 2023Article
- Decoding bladder state from pudendal intraneural signals in pigs.APL bioengineering · 2023Article
- The Fifth Bioelectronic Medicine Summit: today's tools, tomorrow's therapies.Bioelectronic medicine · 2023Article
- Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Posterior Tibial Nerve Stimulation for Overactive Bladder: Mechanism, Classification, and Management Outlines.Parkinson's disease · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Electrical stimulation therapies to promote bladder filling and prevent incontinence deliver continuous inhibitory stimulation, even during bladder emptying. However, continuous inhibitory stimulation that increases bladder capacity (BC) can reduce the efficiency of subsequent voiding (VE). Here we demonstrate that state-dependent stimulation, with different electrical stimulation parameters delivered during filling and emptying can increase both BC and VE relative to continuous stimulation in rats and cats of both sexes. We show that continuous 10 Hz pudendal nerve stimulation increased BC (120-180% of control) but decreased VE (12-71%, relative to control). In addition to increasing BC, state-dependent stimulation in both rats and cats increased VE (280-759% relative to continuous stimulation); motor bursting in cats increased VE beyond the control (no stimulation) condition (males: 323%; females: 161%). These results suggest that a bioelectronic bladder pacemaker can treat complex voiding disorders, including both incontinence and retention, which paradoxically are often present in the same individual.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.