ArticleScientific reports2021
Transcriptomic analysis of early stages of intestinal regeneration in Holothuria glaberrima.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sea CucumberResearch square · 2026Article
- Hepatorenal protective role of encapsulatedJournal of advanced veterinary and animal research · 2026Article
- Echinoderm Radial Glia-Like Cells Express Vertebrate Glial Markers.The Journal of comparative neurology · 2025Article
- Article
- LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumberComputational and structural biotechnology journal · 2025Article
- Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium.bioRxiv : the preprint server for biology · 2024Article
- Sea cucumbers: an emerging system in evo-devo.EvoDevo · 2024Review
- Manipulating Myc for reparative regeneration.Frontiers in cell and developmental biology · 2024Review
- Transcriptomic analysis reveals the early body wall regeneration mechanism of the sea cucumber Holothuria leucospilota after artificially induced transverse fission.BMC genomics · 2023Article
- Characterization and Expression of Holothurian Wnt Signaling Genes during Adult Intestinal Organogenesis.Genes · 2023Article
- Muscle Regeneration in Holothurians without the Upregulation of Muscle Genes.International journal of molecular sciences · 2022Article
- The Stress Response of the Holothurian Central Nervous System: A Transcriptomic Analysis.International journal of molecular sciences · 2022Article
- Characterization and Expression Analysis of Regeneration-Associated Protein (Aj-Orpin) during Intestinal Regeneration in the Sea CucumberMarine drugs · 2022Article
- Twinkle twinkle brittle star: the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research.BMC genomics · 2022Article
- Wnt/β-catenin signaling pathway regulates cell proliferation but not muscle dedifferentiation nor apoptosis during sea cucumber intestinal regeneration.Developmental biology · 2021Article
- Review
- Review
- Regeneration in Echinoderms: Molecular Advancements.Frontiers in cell and developmental biology · 2021Review
- The Role of the Microbiota in Regeneration-Associated Processes.Frontiers in cell and developmental biology · 2021Review
- A roadmap for intestinal regeneration.The International journal of developmental biology · 2021Review
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Authors and funding
5 authors.
Funding
Abstract
Echinoderms comprise a group of animals with impressive regenerative capabilities. They can replace complex internal organs following injury or autotomy. In holothurians or sea cucumbers, cellular processes of intestinal regeneration have been extensively studied. The molecular machinery behind this faculty, however, remains to be understood. Here we assembled and annotated a de novo transcriptome using RNA-seq data consisting of regenerating and non-regenerating intestinal tissues from the sea cucumber Holothuria glaberrima. Comparisons of differential expression were made using the mesentery as a reference against 24 h and 3 days regenerating intestine, revealing a large number of differentially expressed transcripts. Gene ontology and pathway enrichment analysis showed evidence of increasing transcriptional activity. Further analysis of transcripts associated with transcription factors revealed diverse expression patterns with mechanisms involving developmental and cancer-related activity that could be related to the regenerative process. Our study demonstrates the broad and diversified gene expression profile during the early stages of the process using the mesentery as the focal point of intestinal regeneration. It also establishes the genes that are the most important candidates in the cellular processes that underlie regenerative responses.
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