ArticleScientific reports2021
An optomechanogram for assessment of the structural and mechanical properties of tissues.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- From precision to strength: computer vision for suture quality assessment-an ex vivo pilot study.Surgical endoscopy · 2026Article
- Multi-axial strain mapping to characterise structure and material properties of the human hip capsule.PloS one · 2026Article
- Data-driven image analysis to determine antibody-induced dissociation of cell-cell adhesion and antibody pathogenicity in pemphigus.PNAS nexus · 2025Article
- Sustained strain applied at high rates drives dynamic tensioning in epithelial cells.Communications biology · 2025Article
- Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells.bioRxiv : the preprint server for biology · 2025Article
- Impact of paraben on uterine collagen: An integrated and targeted Correlative approach using second harmonic generation microscopy, nanoindentation, and atomic force microscopy.Journal of the mechanical behavior of biomedical materials · 2025Article
- Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma.Scientific reports · 2025Article
- Chronic exposure of mice to phthalates enhances TGF beta signaling and promotes uterine fibrosis.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- An indentation-based framework for probing the glycosaminoglycan-mediated interactions of collagen fibrils.Journal of the mechanical behavior of biomedical materials · 2023Article
- Orientation-dependent indentation reveals the crosslink-mediated deformation mechanisms of collagen fibrils.Acta biomaterialia · 2023Article
- A Micro-Scale Non-Linear Finite Element Model to Optimize the Mechanical Behavior of Bioprinted Constructs.3D printing and additive manufacturing · 2022Article
- Heterogeneous microstructural changes of the cervix influence cervical funneling.Acta biomaterialia · 2022Article
- Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer.BMC medicine · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
The structural and mechanical properties of tissue and the interplay between them play a critical role in tissue function. We introduce the optomechanogram, a combined quantitative and qualitative visualization of spatially co-registered measurements of the microstructural and micromechanical properties of any tissue. Our approach relies on the co-registration of two independent platforms, second-harmonic generation (SHG) microscopy for quantitative assessment of 3D collagen-fiber microstructural organization, and nanoindentation (NI) for local micromechanical properties. We experimentally validate our method by applying to uterine cervix tissue, which exhibits structural and mechanical complexity. We find statistically significant agreement between the micromechanical and microstructural data, and confirm that the distinct tissue regions are distinguishable using either the SHG or NI measurements. Our method could potentially be used for research in pregnancy maintenance, mechanobiological studies of tissues and their constitutive modeling and more generally for the optomechanical metrology of materials.
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