ArticleScientific reports2021
Investigating the optical clearing effects of 50% glycerol in ex vivo human skin by harmonic generation microscopy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Tartrazine clearing of the tympanic membrane for improved visualization of the middle ear.Biomedical optics express · 2026Article
- Spectrally Silent and Optically Transparent: Clear-SiR for Deep Raman Biomolecular Sensing.ACS sensors · 2025Article
- Enhanced penetration depth in optical coherence tomography and photoacoustic microscopyOptica · 2025Article
- Evaluating the effect of glycerol on increasing the safety and efficiency of hyperthermic laser lipolysis.Lasers in medical science · 2024Article
- Silica Nanoparticle-Infused Omniphobic Polyurethane Foam with Bacterial Anti-Adhesion and Antifouling Properties for Hygiene Purposes.Nanomaterials (Basel, Switzerland) · 2023Article
- Spatio-Temporal Dynamics of Diffusion-Associated Deformations of Biological Tissues and Polyacrylamide Gels Observed with Optical Coherence Elastography.Materials (Basel, Switzerland) · 2023Article
- Confocal Raman Micro-Spectroscopy for Discrimination of Glycerol Diffusivity in Ex Vivo PorcineLife (Basel, Switzerland) · 2022Article
- Optical Coherence Elastography as a Tool for Studying Deformations in Biomaterials: Spatially-Resolved Osmotic Strain Dynamics in Cartilaginous Samples.Materials (Basel, Switzerland) · 2022Article
- In vivo harmonic generation microscopy for monitoring the height of basal keratinocytes in solar lentigines after laser depigmentation treatment.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging depth and quality of optical microscopy can be enhanced by optical clearing. Here we investigate the optical clearing of the ex vivo human skin by 50% glycerol topical application, which is allowed for cosmetic usage. Harmonic generation microscopy, by combining second and third harmonic generation (THG) modalities, was utilized to examine the clearing effect. The THG image intensity is sensitive to the improved optical homogeneity after optical clearing, and the second harmonic generation (SHG) image intensity in the dermis could serve as a beacon to confirm the reduction of the scattering in the epidermis layer. As a result, our study supports the OC effect through 50% glycerol topical application. Our study further indicates the critical role of stratum corneum shrinkage for the observed SHG and THG signal recovery.
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Registered trials
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