ArticleNature communications2021
Two novel venom proteins underlie divergent parasitic strategies between a generalist and a specialist parasite.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Host-Associated Differentiation in a Parasitoid Wasp Connected to Venom-Related but Not Chemosensory Genes.Molecular ecology · 2026Article
- Transforming hosts into nurseries and nutrients: strategic manipulation by endoparasitoid wasps.Journal of advanced research · 2026Review
- Novel effector HYPB1 of cotton bollworm (Helicoverpa armigera) inhibits biosynthesis of plant secondary metabolites and promotes feeding by targeting cotton dirigent protein GhDIR15.Journal of integrative plant biology · 2026Article
- An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- A bacterial gene acquired by parasitoid wasps contributes to venom secretion against host defence.The EMBO journal · 2026Article
- A Set of Novel Venom Proteins Enables Parasitoid Wasps to Exploit Older Hosts and Coexist with Competitors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chromosome-level genome assembly of Trichogramma ostriniae Pang & Chen (Hymenoptera: Trichogrammatidae).Scientific data · 2025Article
- Synergistic host-parasitoid antimicrobial peptide interactions ensure the survival of parasitized hosts.Virulence · 2025Article
- Regulation of lipid metabolism in Spodoptera frugiperda by the symbiotic bracovirus of the gregarious parasitoid Cotesia ruficrus.PLoS pathogens · 2025Article
- ThebioRxiv : the preprint server for biology · 2025Article
- Chromosomal-level genome assembly of Trichogramma japonicum (Hymenoptera: Trichogrammatidae).Scientific data · 2025Article
- Article
- A rare, evolutionarily conserved venom protein benefits endoparasitism across parasitoids.Cell genomics · 2025Article
- Rethinking parasitoid venoms: beyond immune suppression.Trends in parasitology · 2025Article
- Venomous Cargo: Diverse Toxin-Related Proteins Are Associated with Extracellular Vesicles in Parasitoid Wasp Venom.Pathogens (Basel, Switzerland) · 2025Article
- Chromosome-level genome sequencing and assembly of the parasitoid wasp Leptopilina myrica.Scientific data · 2025Article
- Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation.International journal of molecular sciences · 2025Review
- Parasitoid wasp venoms degradeScience advances · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasitoids are ubiquitous in natural ecosystems. Parasitic strategies are highly diverse among parasitoid species, yet their underlying genetic bases are poorly understood. Here, we focus on the divergent adaptation of a specialist and a generalist drosophilid parasitoids. We find that a novel protein (Lar) enables active immune suppression by lysing the host lymph glands, eventually leading to successful parasitism by the generalist. Meanwhile, another novel protein (Warm) contributes to a passive strategy by attaching the laid eggs to the gut and other organs of the host, leading to incomplete encapsulation and helping the specialist escape the host immune response. We find that these diverse parasitic strategies both originated from lateral gene transfer, followed with duplication and specialization, and that they might contribute to the shift in host ranges between parasitoids. Our results increase our understanding of how novel gene functions originate and how they contribute to host adaptation.
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