ArticleNature communications2021
Satb2 neurons in the parabrachial nucleus mediate taste perception.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- A pair of interneurons that confer positive real-time valence to sweet sensation in Drosophila.Current biology : CB · 2026Article
- NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025Article
- Ingestion-activated CGRP neurons control learning but not satiety.bioRxiv : the preprint server for biology · 2025Article
- ParabrachialeNeuro · 2025Article
- Gustatory thalamic neurons mediate aversive behaviors.Nature communications · 2025Article
- ParabrachialiScience · 2025Article
- Oral phenotype in SATB2-associated syndrome: cross-sectional study of the French cohort.Orphanet journal of rare diseases · 2025Article
- Article
- Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024Article
- Recent advances in the characterization of genetically defined neurons that regulate internal-state-dependent taste modification in mice.Physiological reports · 2024Review
- Neural circuits for taste sensation.Molecules and cells · 2024Review
- Efferent projections of Nps-expressing neurons in the parabrachial region.The Journal of comparative neurology · 2024Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Involvement of the parabrachial nucleus in emergence from general anesthesia.Frontiers in neuroscience · 2024Review
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.bioRxiv : the preprint server for biology · 2023Article
- A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.Nature neuroscience · 2023Article
- Expression of SATB1 and SATB2 in the brain of bony fishes: what fish reveal about evolution.Brain structure & function · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The neural circuitry mediating taste has been mapped out from the periphery to the cortex, but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a population of neurons in the gustatory region of the parabrachial nucleus that express the transcription factor Satb2 and project to taste-associated regions, including the gustatory thalamus and insular cortex. Using calcium imaging in awake, freely licking mice, we show that Satb2 neurons respond to the five basic taste modalities. Optogenetic activation of these neurons enhances taste preferences, whereas chronic inactivation decreases the magnitude of taste preferences in both brief- and long-access taste tests. Simultaneous inactivation of Satb2 and calcitonin gene-related peptide neurons in the PBN abolishes responses to aversive tastes. These data suggest that taste information in the parabrachial nucleus is conveyed by multiple populations of neurons, including both Satb2 and calcitonin gene-related peptide neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.