ArticleNPJ biofilms and microbiomes2021
Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.
Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 92 citations in OpenAlex.
- A novel stress response pathway mediates biofilm architecture in Pseudomonas aeruginosa.PLoS pathogens · 2026Article
- Genetic diversification ofApplied and environmental microbiology · 2026Article
- Evolutionary drivers of divergent collateral sensitivity responses during antibiotic therapy.Nature ecology & evolution · 2026Review
- A Novel Method to Monitor the Evolution of Antimicrobial Resistance inInternational journal of molecular sciences · 2026Article
- Antibiotic resistance dissemination in soil ecosystems: deep understanding for effective management and global health protection.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models.NPJ biofilms and microbiomes · 2026Article
- Evolved populations ofMicrobial genomics · 2026Article
- Biofilm structure as a key factor in antibiotic tolerance: insights from Bacillus subtilis model systems.NPJ biofilms and microbiomes · 2025Article
- Competition between Pseudomonas species constrains ecological diversification in polymicrobial biofilms.NPJ biofilms and microbiomes · 2025Article
- Cyclic-di-GMP signalling mutants drive ecological succession and self-generated diversity in experimentally evolved biofilms ofMicrobiology (Reading, England) · 2025Article
- Common food preservatives induce an oxidative stress response inMicrobiology (Reading, England) · 2025Article
- Collateral sensitivity and cross-resistance in six species of bacteria exposed to six classes of antibiotics.Microbiology spectrum · 2025Article
- Multidrug Resistance and Virulence Traits ofAntibiotics (Basel, Switzerland) · 2025Article
- Comparative Effects of Intermittent vs. Constant Ceftiofur Hydrochloride Exposure onAntibiotics (Basel, Switzerland) · 2025Article
- Mechanistic insights and therapeutic innovations in engineered nanomaterial-driven disruption of biofilm dynamics.RSC advances · 2025Review
- Student-led experimental evolution reveals novel biofilm regulators of adaptation to multiple niches.bioRxiv : the preprint server for biology · 2025Article
- Fermentation Products Originated fromBiology · 2025Article
- Tazobactam selects for multidrug resistance.npj antimicrobials and resistance · 2025Article
- Increased Expression of AbcA Efflux Pump Accelerated Resistance Development from Tolerance to Resistance Against Oxacillin inMicroorganisms · 2025Article
- Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts.Biology · 2025Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Most bacteria in nature exist in biofilms, which are inherently tolerant to antibiotics. There is currently very limited understanding of how biofilms evolve in response to sub-lethal concentrations of antimicrobials. In this study, we use a biofilm evolution model to study the effects of sub-inhibitory concentrations of three antibiotics on Salmonella Typhimurium biofilms. We show that biofilms rapidly evolve resistance to each antibiotic they are exposed to, demonstrating a strong selective pressure on biofilms from low antibiotic concentrations. While all antibiotics tested select for clinical resistance, there is no common mechanism. Adaptation to antimicrobials, however, has a marked cost for other clinically important phenotypes, including biofilm formation and virulence. Cefotaxime selects mutants with the greatest deficit in biofilm formation followed by azithromycin and then ciprofloxacin. Understanding the impacts of exposure of biofilms to antibiotics will help understand evolutionary trajectories and may help guide how best to use antibiotics in a biofilm context. Experimental evolution in combination with whole-genome sequencing is a powerful tool for the prediction of evolution trajectories associated with antibiotic resistance in biofilms.
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Registered trials
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