ArticleCell death & disease2021
Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.
Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- A bacterial CARD-NLR-like immune system controls the release of gene transfer agents.Nature microbiology · 2026Article
- Autophagy regulation of pyroptosis and ferroptosis: a new strategy for colorectal cancer treatment.Apoptosis : an international journal on programmed cell death · 2026Review
- Pyroptosis, A Double-Edged Sword in Respiratory Diseases: A Narrative Review.Journal of inflammation research · 2026Review
- Atomic mechanisms of full-length ASC-mediated inflammasome assembly.Nature communications · 2025Article
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- Role of inflammasomes and neuroinflammation in epilepsy.Immunological reviews · 2025Review
- Article
- NLRP inflammasomes in health and disease.Molecular biomedicine · 2024Review
- Inflammasomes in neurological disorders - mechanisms and therapeutic potential.Nature reviews. Neurology · 2024Review
- The role of inflammasomes in human diseases and their potential as therapeutic targets.Signal transduction and targeted therapy · 2024Review
- NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise.Communications biology · 2023Review
- Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.Annual review of immunology · 2023Review
- Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases.Journal of neuroinflammation · 2022Article
- The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation.Frontiers in immunology · 2022Article
- Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death.Biochemical Society transactions · 2021Review
- Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases.Cell death & disease · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosolic inflammasomes are supramolecular complexes that are formed in response to intracellular pathogens and danger signals. However, as to date, the detailed description of a homotypic caspase recruitment domain (CARD) interaction between NLRP1 and ASC has not been presented. We found the CARD-CARD interaction between purified NLRP1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.