Evidence map›Paper›PMID 33431705›Full record

ArticleInfection and immunity2021

Regulation of the

Arturo Casas, Dennis Hawisher, Christian B De Guzman, Stephen W Bickler, Antonio De Maio, David M Cauvi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arturo CasasInitiative for Maximizing Student Development Program, University of California-San Diego, La Jolla, California, USA Arturo.CasasJr@UTSouthwestern.edu dcauvi@health.ucsd.edu.
Dennis HawisherDivision of Trauma, Critical Care, Burns and Acute Care Surgery, Department of Surgery, School of Medicine, University of California-San Diego, La Jolla, California, USA.
Christian B De GuzmanDivision of Trauma, Critical Care, Burns and Acute Care Surgery, Department of Surgery, School of Medicine, University of California-San Diego, La Jolla, California, USA.
Stephen W BicklerDivision of Trauma, Critical Care, Burns and Acute Care Surgery, Department of Surgery, School of Medicine, University of California-San Diego, La Jolla, California, USA.
Antonio De MaioInitiative for Maximizing Student Development Program, University of California-San Diego, La Jolla, California, USA.
David M CauviDivision of Trauma, Critical Care, Burns and Acute Care Surgery, Department of Surgery, School of Medicine, University of California-San Diego, La Jolla, California, USA Arturo.CasasJr@UTSouthwestern.edu dcauvi@health.ucsd.edu.ORCID 0000-0003-0865-4802
University of California San Diego · US

Funding

Mentoring Young Minds to Increase Diversity in the Biomedical ResearchR25GM083275 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DE MAIO, ANTONIO, LAWSON, MARK ANDREW · 2008 to 2022
$9.9M
NIGMS NIH HHS R25 GM083275
6 · The paper itself

Abstract

Sepsis is a life-threatening condition that arises from a poorly regulated inflammatory response to pathogenic organisms. Current treatments are limited to antibiotics, fluid resuscitation, and other supportive therapies. New targets for monitoring disease progression and therapeutic interventions are therefore critically needed. We previously reported that lipocalin-2 (Lcn2), a bacteriostatic mediator with potent proapoptotic activities, was robustly induced in sepsis. Other studies showed that

Indexed as

Disease SusceptibilityAdaptor Proteins, Signal TransducingAnimalsAnimals, Outbred StrainsDisease Models, AnimalI-kappa B ProteinsLipocalin-2LipopolysaccharidesMacrophagesMiceSepsisShock, SepticAdaptor Proteins, Signal TransducingI-kappa B ProteinsLcn2 protein, mouseLipocalin-2LipopolysaccharidesNfkbiz protein, mouseendotoxemiaIkBζinnate immunityNfkbizsepsis

Identifiers

PMID33431705
PMCPMC8090956
OpenAlexW3120304703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.