Evidence map›Paper›PMID 33431701›Full record

ArticleInfection and immunity2021

Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity.

Natalya I Motyka, Sydney R Stewart, Ian E Hollifield, Thomas R Kyllo, Joshua A Mansfield, Elizabeth B Norton, John D Clements, Jacob P Bitoun

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  3. Article
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  11. EnterotoxigenicInfection and immunity · 2022
    Article
  12. EnterotoxigenicGut microbes
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Natalya I MotykaDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Sydney R StewartDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Ian E HollifieldDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Thomas R KylloDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Joshua A MansfieldDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Elizabeth B NortonDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
John D ClementsDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Jacob P BitounDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA jbitoun@tulane.edu.ORCID 0000-0001-7110-2328
Tulane University · US

Funding

The Role of STa in ETEC PathogenesisR01AI125542 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI BITOUN, JACOB P. · 2017 to 2020
$1.5M
Development of an ETEC multivalent subunit vaccine using outer membrane vesiclesR21AI190682 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Jacob P. Bitoun · 2025 to 2026
$415k
The Role of STa in ETEC PathogenesisR56AI125542 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI BITOUN, JACOB P. · 2016 to 2016
$376k
Mechanisms of dmLT AdjuvantR56AI143937 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NORTON, ELIZABETH B · 2020 to 2020
$261k
NIAID NIH HHS R01 AI125542NIAID NIH HHS R21 AI190682NIAID NIH HHS R56 AI125542NIAID NIH HHS R56 AI143937
6 · The paper itself

Abstract

Enterotoxigenic

Indexed as

AnimalsCell LineCyclic GMPCytokinesDisease Models, AnimalEnterotoxigenic Escherichia coliEnterotoxinsEscherichia coli InfectionsFemaleHost-Pathogen InteractionsHumansImmunity, MucosalImmunizationInflammation MediatorsInterleukin-33Intestinal MucosaCyclic GMPCytokinesEnterotoxinsInflammation MediatorsInterleukin-33enterotoxinsinflammationintestinal immunity

Identifiers

PMID33431701
PMCPMC8090939
OpenAlexW3121045682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.