Evidence map›Paper›PMID 33431692›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning.

Pavlo A Nesterenko, Jami McLaughlin, Donghui Cheng, Nathanael J Bangayan, Giselle Burton Sojo, Christopher S Seet, Yu Qin, Zhiyuan Mao, Matthew B Obusan, John W Phillips and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Defining T cell receptor repertoires using nanovial-based binding and functional screening.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. HLA-ACell reports · 2021
    Article
  14. Single-cell analysis of immune repertoires enabled.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Pavlo A NesterenkoMolecular Biology Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0001-9841-8170
Jami McLaughlinDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Donghui ChengDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Nathanael J BangayanDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
Giselle Burton SojoDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Christopher S SeetDivision of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Yu QinDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Zhiyuan MaoDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
Matthew B ObusanDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.ORCID 0000-0002-9579-2308
John W PhillipsDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Owen N WitteMolecular Biology Institute, University of California, Los Angeles, CA 90095; owenwitte@mednet.ucla.edu.ORCID 0000-0003-4461-4533
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
Targeting alternative splicing for TCR discovery in small cell carcinomasU01CA233074 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CROOKS, GAY M, WITTE, OWEN N. · 2018 to 2022
$4.1M
NCI NIH HHS P30 CA016042NCI NIH HHS T32 CA009056NCI NIH HHS T32 CA009120NCI NIH HHS U01 CA233074NIAID NIH HHS P30 AI028697
6 · The paper itself

Abstract

T cell receptors (TCRs) are generated by somatic recombination of V/D/J segments to produce up to 10

Indexed as

CD8-Positive T-LymphocytesCloning, MolecularCytomegalovirusEpitopesEpstein-Barr Virus InfectionsForkhead Transcription FactorsHerpesvirus 4, HumanHumansInterferon-gammaReceptors, Antigen, T-CellRNA, MessengerRNA-SeqSingle-Cell AnalysisT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaV(D)J RecombinationEpitopesForkhead Transcription FactorsFOXP3 protein, humanIFNG protein, humanInterferon-gammaReceptors, Antigen, T-CellRNA, MessengerTumor Necrosis Factor-alphamRNA sequencingsingle-cell sequencingT cell receptorT cellsTCR

Identifiers

PMID33431692
PMCPMC7826406
OpenAlexW3120099127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.