ArticleProceedings of the National Academy of Sciences of the United States of America2021
Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1.bioRxiv : the preprint server for biology · 2026Article
- Representations of social experience in hippocampal circuits.Trends in cognitive sciences · 2026Review
- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
- Hippocampal CA2 to CA1: A metaplastic switch for memory encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Temporal encoding in deep reinforcement learning agents.Scientific reports · 2023Article
- A neural code for time and space in the human brain.Cell reports · 2023Article
- Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- CA2 orchestrates hippocampal network dynamics.Hippocampus · 2023Review
- Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle.Scientific reports · 2023Article
- Thunderstruck: The ACDC model of flexible sequences and rhythms in recurrent neural circuits.PLoS computational biology · 2022Article
- Dynamic Hippocampal CA2 Responses to Contextual Spatial Novelty.Frontiers in systems neuroscience · 2022Article
- Differential involvement of CA2 in internally vs. externally driven hippocampal sequences.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reply to Lehr and Stöber: What's in a name? On the distinction between temporal coding and internally driven activity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regulation of the Brain Neural Niche by Soluble Molecule Akhirin.Journal of developmental biology · 2021Review
- RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain.International journal of molecular sciences · 2021Review
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2 authors at 1 institution in 1 country.
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Abstract
There is considerable evidence for hippocampal time cells that briefly activate in succession to represent the temporal structure of memories. Previous studies have shown that time cells can be disrupted while leaving place cells intact, indicating that spatial and temporal information can be coded in parallel. However, the circuits in which spatial and temporal information are coded have not been clearly identified. Here we investigated temporal and spatial coding by dorsal hippocampal CA1 (dCA1) neurons in mice trained on a classic spatial working-memory task. On each trial, the mice approached the same choice point on a maze but were trained to alternate between traversing one of two distinct spatial routes (spatial coding phase). In between trials, there was a 10-s mnemonic delay during which the mouse continuously ran in a fixed location (temporal coding phase). Using cell-type-specific optogenetic methods, we found that inhibiting dorsal CA2 (dCA2) inputs into dCA1 degraded time cell coding during the mnemonic delay and impaired the mouse's subsequent memory-guided choice. Conversely, inhibiting dCA2 inputs during the spatial coding phase had a negligible effect on place cell activity in dCA1 and no effect on behavior. Collectively, our work demonstrates that spatial and temporal coding in dCA1 is largely segregated with respect to the dCA2-dCA1 circuit and suggests that CA2 plays a critical role in representing the flow of time in memory within the hippocampal network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.