ArticleProceedings of the National Academy of Sciences of the United States of America2021
Spatial and evolutionary predictability of phytochemical diversity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed.
- Identification and characterization of five anti-mitotic sesquiterpene lactones fromPharmaceutical biology · 2026Article
- Climate Shapes Elevational Gradients in Concentration, Composition, and Functional Diversity of Willow Metabolomes.Plant, cell & environment · 2026Article
- eCOMET: an R package for evaluating metabolic diversity and enrichment from LC-MS/MS data to test ecological hypotheses from individuals to ecosystems.The New phytologist · 2026Article
- Exploring phytochemical variability in Iranian Acanthophyllum (Caryophyllaceae) species: insights for enhanced medicinal and industrial utilization.BMC plant biology · 2026Article
- Metabolome Reprogramming During Fruit Ripening and Post-Harvest Storage in Ten Crop Species.Metabolites · 2026Article
- METRIN-KG: A knowledge graph integrating plant metabolites, traits, and biotic interactions.GigaScience · 2026Article
- The Metabolic Diversity of DifferentPlants (Basel, Switzerland) · 2026Article
- Untargeted metabolomics as a new perspective for assessing taxonomic boundaries in alpine Rubus genus.PloS one · 2026Article
- Editorial: Exploring the role of plant phytochemical diversity in biodiversity and beyond.Frontiers in plant science · 2026Article
- Scents on the slope: declining volatile emissions but stable predator-associated cues across elevation in alpine willows.Frontiers in plant science · 2026Article
- Seasonal Variation in Essential Oil Composition and Yield ofMolecules (Basel, Switzerland) · 2025Article
- Beyond phylogeny: phytochemical diversity as a unique metric for biodiversity in the Gentianales.The New phytologist · 2025Article
- The Role of Nucleotide Sequencing in Natural Product Drug Discovery.Journal of natural products · 2025Review
- Omics-based profiling and therapeutic potential of natural components in pan-Shennongjia medicinal herbs.Chinese medicine · 2025Article
- Selection strengthens the relationship between plant diversity and the metabolic profile of Plantago lanceolata.The New phytologist · 2025Article
- The influence of aridity on plant intraspecific chemical diversity supports adaptive differentiation and convergent evolution.Plant biology (Stuttgart, Germany) · 2025Article
- Article
- Evolutionary Trajectories of Shoots vs. Roots: Plant Volatile Metabolomes Are Richer but Less Structurally Diverse Belowground in the Tropical Tree GenusPlants (Basel, Switzerland) · 2025Article
- Effects of site elevation and grazing exclusion on phenolic compound production in Nardus stricta plants in high-elevation grasslands.PloS one · 2025Article
- Accessible versatility underpins the deep evolution of plant specialized metabolism.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2025Review
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To cope with environmental challenges, plants produce a wide diversity of phytochemicals, which are also the source of numerous medicines. Despite decades of research in chemical ecology, we still lack an understanding of the organization of plant chemical diversity across species and ecosystems. To address this challenge, we hypothesized that molecular diversity is not only related to species diversity, but also constrained by trophic, climatic, and topographical factors. We screened the metabolome of 416 vascular plant species encompassing the entire alpine elevation range and four alpine bioclimatic regions in order to characterize their phytochemical diversity. We show that by coupling phylogenetic information, topographic, edaphic, and climatic variables, we predict phytochemical diversity, and its inherent composition, of plant communities throughout landscape. Spatial mapping of phytochemical diversity further revealed that plant assemblages found in low to midelevation habitats, with more alkaline soils, possessed greater phytochemical diversity, whereas alpine habitats possessed higher phytochemical endemism. Altogether, we present a general tool that can be used for predicting hotspots of phytochemical diversity in the landscape, independently of plant species taxonomic identity. Such an approach offers promising perspectives in both drug discovery programs and conservation efforts worldwide.
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