ReviewProceedings of the National Academy of Sciences of the United States of America2021
An evidence review of face masks against COVID-19.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 580 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
580 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,290 citations in OpenAlex.
- Evidence of Face Masks and Masking Policies for the Prevention of SARS-CoV-2 Transmission and COVID-19 in Real-World Settings: A Systematic Literature Review.International journal of environmental research and public health · 2025Pooled it
- Increasing Face Mask Wearing in Autistic Individuals Using Behavior Analytic Interventions: A Systematic Review and Meta-analysis.Journal of autism and developmental disorders · 2024Pooled it
- Masks and respirators for prevention of respiratory infections: a state of the science review.Clinical microbiology reviews · 2024Pooled it
- Asian American Vaccination, Testing, and Other Healthcare Knowledge & Behaviors during COVID-19, A Systematic Review.Pathogens and global health · 2023Pooled it
- Physio-metabolic and clinical consequences of wearing face masks-Systematic review with meta-analysis and comprehensive evaluation.Frontiers in public health · 2023Pooled it
- Investigating effects of FFP2 wearing during physical activity on gas exchange, metabolism and affective state using a randomized controlled trial.Scientific reports · 2024Trial
- Theory-based Trial to Promote Uptake and Sustained Use of Face Coverings During the COVID-19 Pandemic.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Trial
- Effects of Mask Reuse on the Oropharyngeal, Skin, and Mask Microbiome.The Journal of infectious diseases · 2023Trial
- Influence of short-term face mask wear on semiautomatically measured tear film parameters in dry eye patients and healthy volunteers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Trial
- Trial
- Effect of Wearing a Face Mask on Hand-to-Face Contact by Children in a Simulated School Environment: The Back-to-School COVID-19 Simulation Randomized Clinical Trial.JAMA pediatrics · 2022Trial
- Parents' Multiperspective Views and Misinformation About COVID-19 Mitigation Measures During Tennessee School Board Meetings: Qualitative Content Analysis Using YouTube.JMIR infodemiology · 2026Article
- Estimating the effect of self-protection on transmission dynamics of SARS-CoV-2 in Germany in 2021: a modelling study.BMC public health · 2026Article
- Comparison of Mask-Wearing Behavior on Social Media and Its Relationship With Demographic Characteristics During the COVID-19 Pandemic: Social Media Data Analysis Between the United States and Japan.JMIR human factors · 2026Article
- Investigation of Community Behaviors, Socioeconomic Factors, and Breakthrough COVID-19 Infections Among Vaccinated Individuals: Cross-Sectional Study.Online journal of public health informatics · 2026Article
- The COVID-19 pandemic could worsen the psychological well-being of people with disabilities in Cambodia.Scientific reports · 2026Article
- Uncovering the biases: why the claimed mask-excess mortality link fails to hold.Lancet regional health. Americas · 2026Article
- Short-time thermal inactivation of surrogates of the public transport microbiome with a low-cost thermoresistometer.Scientific reports · 2026Article
- Face mask littering: environmental impacts, regulatory challenges, and AI-driven waste management strategies for the postpandemic era.Turkish journal of medical sciences · 2026Review
- SARS-CoV-2 infection in dogs, dog owners, dog breeders, and veterinarians in the Ashanti and Greater Accra regions of Ghana-zoonotic implications.Frontiers in veterinary science · 2026Article
520 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
19 authors at 15 institutions in 7 countries.
Funding
Abstract
The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wearer protection, sociological considerations, and implementation considerations. A primary route of transmission of COVID-19 is via respiratory particles, and it is known to be transmissible from presymptomatic, paucisymptomatic, and asymptomatic individuals. Reducing disease spread requires two things: limiting contacts of infected individuals via physical distancing and other measures and reducing the transmission probability per contact. The preponderance of evidence indicates that mask wearing reduces transmissibility per contact by reducing transmission of infected respiratory particles in both laboratory and clinical contexts. Public mask wearing is most effective at reducing spread of the virus when compliance is high. Given the current shortages of medical masks, we recommend the adoption of public cloth mask wearing, as an effective form of source control, in conjunction with existing hygiene, distancing, and contact tracing strategies. Because many respiratory particles become smaller due to evaporation, we recommend increasing focus on a previously overlooked aspect of mask usage: mask wearing by infectious people ("source control") with benefits at the population level, rather than only mask wearing by susceptible people, such as health care workers, with focus on individual outcomes. We recommend that public officials and governments strongly encourage the use of widespread face masks in public, including the use of appropriate regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.