Evidence map›Paper›PMID 33431589›Full record

ArticlePediatrics2021

Use of E-cigarettes and Other Tobacco Products and Progression to Daily Cigarette Smoking.

John P Pierce, Ruifeng Chen, Eric C Leas, Martha M White, Sheila Kealey, Matthew D Stone, Tarik Benmarhnia, Dennis R Trinidad, David R Strong, Karen Messer

Open access · bronzeAbstract read
In one paragraph

Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Initial Subjective Response to Nicotine Vaping Predicts Subsequent E-Cigarette Use in Early Adolescence: An ABCD Investigation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  5. Article
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  7. Tobacco Susceptibility and Use Among Rural Adolescents: The Role of Tobacco Marketing Exposure and Screen Media Use.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
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  11. A Qualitative Analysis of How Underage Adolescents Access Nicotine Vaping Products in Aotearoa New Zealand.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

John P PierceHerbert Wertheim School of Public Health and Human Longevity Science, jppierce@ucsd.edu.
Ruifeng ChenHerbert Wertheim School of Public Health and Human Longevity Science.
Eric C LeasHerbert Wertheim School of Public Health and Human Longevity Science.
Martha M WhiteMoores Cancer Center, and.
Sheila KealeyMoores Cancer Center, and.
Matthew D StoneHerbert Wertheim School of Public Health and Human Longevity Science.
Tarik BenmarhniaHerbert Wertheim School of Public Health and Human Longevity Science.
Dennis R TrinidadHerbert Wertheim School of Public Health and Human Longevity Science.
David R StrongHerbert Wertheim School of Public Health and Human Longevity Science.
Karen MesserHerbert Wertheim School of Public Health and Human Longevity Science.
Human Longevity (United States) · USMoores Cancer Center

Funding

The role of ENDS use in changing rates of escalation and quitting of cigarette smoking in those under age 35 years in US populationR01CA234539 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENMARHNIA, TARIK, PIERCE, JOHN P · 2018 to 2020
$1.2M
NCI NIH HHS R01 CA234539
6 · The paper itself

Abstract

objectivesTo identify predictors of becoming a daily cigarette smoker over the course of 4 years.

methodsWe identified 12- to 24-year-olds at wave 1 of the US Population Assessment of Tobacco and Health Study and determined ever use, age at first use, and daily use through wave 4 for 12 tobacco products.

resultsSixty-two percent of 12- to 24-year-olds (95% confidence interval [CI]: 60.1% to 63.2%) tried tobacco, and 30.2% (95% CI: 28.7% to 31.6%) tried ≥5 tobacco products by wave 4. At wave 4, 12% were daily tobacco users, of whom 70% were daily cigarette smokers (95% CI: 67.4% to 73.0%); daily cigarette smoking was 20.8% in 25- to 28-year-olds (95% CI: 18.9% to 22.9%), whereas daily electronic cigarette (e-cigarette) vaping was 3.3% (95% CI: 2.4% to 4.4%). Compared with single product triers, the risk of progressing to daily cigarette smoking was 15 percentage points higher (adjusted risk difference [aRD] 15%; 95% CI: 12% to 18%) among those who tried ≥5 products. In particular, e-cigarette use increased the risk of later daily cigarette smoking by threefold (3% vs 10%; aRD 7%; 95% CI: 6% to 9%). Daily smoking was 6 percentage points lower (aRD -6%; 95% CI: -8% to -4%) for those who experimented after age 18 years.

conclusionsTrying e-cigarettes and multiple other tobacco products before age 18 years is strongly associated with later daily cigarette smoking. The recent large increase in e-cigarette use will likely reverse the decline in cigarette smoking among US young adults.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsAdolescentChildCigarette SmokingFemaleHumansLongitudinal StudiesMalePopulation SurveillanceSmokingUnited StatesVapingYoung Adult

Identifiers

PMID33431589
PMCPMC7849197
OpenAlexW3118972431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.