ReviewCold Spring Harbor perspectives in biology2021
Of Cells, Strands, and Networks: Auxin and the Patterned Formation of the Vascular System.
Review in Cold Spring Harbor perspectives in biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Origin and diversity of leaf vein patterns.Journal of experimental botany · 2026Review
- Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram.Nature communications · 2026Article
- The role of auxin transport through plasmodesmata in leaf vein canalization and patterning.Frontiers in plant science · 2025Article
- Over 25 years of decrypting PIN-mediated plant development.Nature communications · 2024Review
- Large Vascular Bundle Phloem Area 4 enhances grain yield and quality in rice via source-sink-flow.Plant physiology · 2023Article
- Leaf vein patterning is regulated by the aperture of plasmodesmata intercellular channels.PLoS biology · 2022Article
- A genetic framework for proximal secondary vein branching in the Arabidopsis thaliana embryo.Development (Cambridge, England) · 2022Article
- Fourteen Stations of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin.The New phytologist · 2022Review
- Fossils and plant evolution: structural fingerprints and modularity in the evo-devo paradigm.EvoDevo · 2022Review
- A perspective on the molecular mechanism in the control of organ internal (IN) asymmetry during petal development.Horticulture research · 2022Article
- Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Throughout plant development, vascular cells continually form from within a population of seemingly equivalent cells. Vascular cells connect end to end to form continuous strands, and vascular strands connect at both or either end to form networks of exquisite complexity and mesmerizing beauty. Here we argue that experimental evidence gained over the past few decades implicates the plant hormone auxin-its production, transport, perception, and response-in all the steps that lead to the patterned formation of the plant vascular system, from the formation of vascular cells to their connection into vascular networks. We emphasize the organizing principles of the cell- and tissue-patterning process, rather than its molecular subtleties. In the picture that emerges, cells compete for an auxin-dependent, cell-polarizing signal; positive feedback between cell polarization and cell-to-cell movement of the polarizing signal leads to gradual selection of cell files; and selected cell files differentiate into vascular strands that drain the polarizing signal from the neighboring cells. Although the logic of the patterning process has become increasingly clear, the molecular details remain blurry; the future challenge will be to bring them into razor-sharp focus.
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