ArticleBMJ case reports2021
Primary Sjögren's syndrome manifesting as sclerotic metabolic bone disease.
Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Hypokalemic rhabdomyolysis due to concurrent distal renal tubular acidosis and Fanconi syndrome in a pediatric patient with Sjögren syndrome.CEN case reports · 2025Article
- Renal tubular acidosis: Varied aetiologies and clinical presentations: Three case reports.World journal of nephrology · 2025Article
- Superscan Pattern on Bone Scintigraphy: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Primary Sjogren's syndrome presenting as hypokalaemic periodic paralysis and acute pancreatitis.BMJ case reports · 2024Article
- Secondary distal renal tubular acidosis and sclerotic metabolic bone disease in seronegative spondyloarthropathy.BMJ case reports · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary Sjögren's syndrome (pSS) is a chronic slowly progressive autoimmune disease characterised by lymphocytic infiltration of salivary and lacrimal glands with varying degree of systemic involvement. Renal involvement, a recognised extraglandular manifestation of pSS, is commonly related to tubular dysfunction and generally manifests as distal renal tubular acidosis (RTA), proximal RTA, tubular proteinuria and nephrogenic diabetes insipidus. Untreated long-standing RTA is known to cause metabolic bone disease. Here, we present the report of a patient with sclerotic metabolic bone disease related to pSS with combined distal and proximal RTA and negative workup for other causes of sclerotic bone disease. A significant clinical and biochemical improvement, including recovery of proximal tubular dysfunction, was noted with alkali therapy. This case suggests the need to consider pSS in the diagnostic algorithm of a patient presenting with sclerotic bone disease.
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