ArticleBMC cancer2021
Current lung cancer screening guidelines may miss high-risk population: a real-world study.
Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 55 citations in OpenAlex.
- Differentiating benign from malignant pulmonary nodules in the context of bronchiectasis: a retrospective study.Annals of medicine · 2026Article
- Epidemiological characteristics and risk factors of lung cancer in a population with incidental pulmonary nodules in China: a prospective multicenter study of 10,560 cases.Journal of the National Cancer Center · 2026Article
- Comparative analysis of lung cancer risk factors between never-smokers and heavy smokers: a nationwide population-based study in Korea.Translational lung cancer research · 2026Article
- Clinical characteristics and survival in early-onset lung cancer: a multicenter cohort study.Frontiers in oncology · 2026Article
- Early Detection of Lung Cancer: A Review of Innovative Milestones and Techniques.Journal of clinical medicine · 2025Review
- Lessons Learned From International Lung Cancer Screening Trials; People at Risk Deserve Screening for Early Detection.Respirology (Carlton, Vic.) · 2025Review
- China Protocol for early screening, precise diagnosis, and individualized treatment of lung cancer.Signal transduction and targeted therapy · 2025Review
- Clinical analysis of incidental discovery of pulmonary nodules with computed tomography: a retrospective cohort study.Journal of thoracic disease · 2025Article
- Lung Cancer Screening in the Incarcerated Population Through a Community Imaging Partnership.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2025Article
- Ploidy status analysis in small cell lung cancer cells and its use in cytopathological diagnosis.International journal of clinical and experimental pathology · 2025Article
- Interpretable machine learning model for digital lung cancer prescreening in Chinese populations with missing data.NPJ digital medicine · 2024Article
- A 16-year evaluation of opportunistic lung cancer screening with low-dose CT in China: comparative findings between non-smokers and smokers.BMC cancer · 2024Article
- A clinically effective model based on cell-free DNA methylation and low-dose CT for risk stratification of pulmonary nodules.Cell reports. Medicine · 2024Article
- Assessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines.BMC medicine · 2024Article
- The insufficiency of CT examination in early detection of central lung squamous cell carcinoma and squamous epithelial precancerous lesions.BMC cancer · 2024Article
- LDCT screening results among eligible and ineligible screening candidates in preventive health check-ups population: a real world study in West China.Scientific reports · 2024Article
- Stakeholders' Voices of Lung Cancer Screening in Hong Kong: Study Protocol for a Mixed Methods Study.Healthcare (Basel, Switzerland) · 2024Article
- Article
- TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk.BMC cancer · 2023Article
- CTCs Detection and Whole-exome Sequencing Might Be Used to Differentiate Benign and Malignant Pulmonary Nodules.Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population. We therefore did a real-world study using the current lung cancer screening guidelines to a health examination population in China to determine the proportion of lung cancer cases that have been missed.
methodsA real-world cohort study of screening, with the use of low-dose computed tomography, was conducted among people who took yearly health checkup in health management center of West China Hospital between 2006 and 2017. We respectively used current guidelines including lung cancer screening guidelines of the U.S. Preventive Services Task Force (USPSTF) and expert consensus on low dose spiral CT lung cancer screening in China.
resultsIn a total of 15,996 participants with health examination who completed the baseline screening, 6779 (42.4%) subjects had at least one positive finding, and 142 (2.1%) cases of lung cancer were screened positive. The false positive rate was 97.9%. Of 142 lung cancer cases detected in our study, only 9.2% met the lung cancer screening guidelines proposed by the USPSTF, and 24.4% met that of China. The rates of missed diagnosis were as high as 90.8 and 75.6% respectively. In addition, we did an in-depth analysis by gender. We found that among male patients with lung cancer, the proportion of smokers was 75%, and the proportion of young people under 50 was 23.2%. Among female patients with lung cancer, the proportion of smokers was only 5.8%, and the proportion of young people under 50 was up to 33.3%.
conclusionsThe rate of missed diagnosis was as high as 90.8% applying the current lung cancer screening guidelines to the health examination population in China. Further study to determine screening guidelines for targeted populations, is warranted.
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