Evidence map›Paper›PMID 33430786›Full record

SynthesisBMC infectious diseases2021

HIV infection and multidrug resistant tuberculosis: a systematic review and meta-analysis.

Zeeba Zahra Sultana, Farhana Ul Hoque, Joseph Beyene, Md Akhlak-Ul-Islam, Md Hasinur Rahman Khan, Shakil Ahmed, Delwer Hossain Hawlader, Ahmed Hossain

Erratum issuedOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Zeeba Zahra SultanaCAPABLE- A Cambridge-led program in Bangladesh, University of Cambridge, Cambridge, UK.
Farhana Ul HoqueDepartment of Public Health, North South University, Dhaka, Bangladesh.
Joseph BeyeneDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Md Akhlak-Ul-IslamDepartment of Hematology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Md Hasinur Rahman KhanInstitute of Statistical Research and Training, University of Dhaka, Dhaka, Bangladesh.
Shakil AhmedGlobal Health Institute, North South University, Dhaka, Bangladesh.
Delwer Hossain HawladerHealth Management BD Foundation, Dhaka, Bangladesh.
Ahmed HossainDepartment of Public Health, North South University, Dhaka, Bangladesh. ahmed.hossain@utoronto.ca.ORCID http://orcid.org/0000-0003-4575-1273
North South University · BDBangladesh Medical University · BDBangladesh University · BDChild Health Research Foundation · BDImpact · CAUniversity of Dhaka · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultidrug-resistant tuberculosis (MDR-TB) in HIV infected individuals is a serious threat to global efforts to combat tuberculosis. Inconsistent findings on the association between HIV infection and MDR-TB were present in many studies. We aimed to review existing data on the relationship between HIV infection and MDR-TB systematically to assess the contribution of HIV on MDR-TB worldwide. We also investigated the patterns of MDR-TB by age, country-wise income, study designs, and global regions.

methodsWe utilized PubMed, Google Scholar, and ScienceDirect databases to select eligible studies for meta-analysis that were published between January 12,010, and July 30, 2020. The random-effects model was used to obtain the pooled odds ratio of the crude association between HIV and MDR-TB with a 95% confidence interval. We investigated the potential publication-bias by checking funnel plot asymmetry and using the Egger's test. Moreover, we assessed the heterogeneity using the I

resultsWe identified 1603 studies through a database search, and after subsequent eliminations we selected 54 studies including 430,534 TB patients. The pooled odds of MDR-TB was 1.42 times higher in HIV-positive patients than HIV-negative patients (OR=1.42,CI=1.17-1.71, I

conclusionSuch findings indicate that HIV infection raises the risk of MDR-TB, and after contrasting it with the results of the earlier pooled study, it appeared to be an upward risk trend. Moreover, we found that the risk is the highest in the South-East Asian region. A balanced allocation of resources is needed to halt both primary and secondary MDR-TB, particularly in HIV infected people with 40 years of age and older.

Indexed as

AdultAfricaAIDS-Related Opportunistic InfectionsAntitubercular AgentsAsia, SoutheasternEuropeFemaleHIVHumansMaleMiddle AgedMycobacterium tuberculosisOdds RatioRiskTuberculosis, Multidrug-ResistantAntitubercular AgentsDrug-resistantHIVMDR-TBMeta-analysisMultidrug resistantTuberculosis

Identifiers

PMID33430786
PMCPMC7802168
OpenAlexW3120055490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.