Evidence map›Paper›PMID 33430685›Full record

ArticleBrain connectivity2021

Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease.

Robert X Smith, Jeremy F Strain, Aaron Tanenbaum, Anne M Fagan, Jason Hassenstab, Eric McDade, Suzanne E Schindler, Brian A Gordon, Chengjie Xiong, Jasmeer Chhatwal and 21 more

Open access · greenAbstract read
In one paragraph

Article in Brain connectivity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

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  17. Review
  18. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 11 institutions in 3 countries.

Robert X SmithDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Jeremy F StrainDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Aaron TanenbaumDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Anne M FaganDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Jason HassenstabDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Eric McDadeDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Suzanne E SchindlerDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Brian A GordonDepartment of Radiology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Chengjie XiongDepartment of Biostatistics, Washington University in Saint Louis, St. Louis, Missouri, USA.
Jasmeer ChhatwalDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Clifford JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Celeste KarchHope Center for Neurological Disorders, Knight ADRC, Washington University, St. Louis, Missouri, USA.
Sarah BermanDepartment of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jared R BroschDepartment of Neurology, Indiana University, Indianapolis, Indiana, USA.
James J LahDepartment of Neurology, Emory University, Atlanta, Georgia, USA.
Adam M BrickmanDepartment of Neurology, Columbia University, New York, New York, USA.
David M CashDepartment of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
Nick C FoxDepartment of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
Johannes LevinGerman Center for Neurodegenerative Disease (DZNE) Munich, Munich, Germany.
James NobleDepartment of Neurology, Columbia University, New York, New York, USA.
David M HoltzmanDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Colin L MastersThe Florey Institute, University of Melbourne, Parkvile, Australia.
Martin R FarlowDepartment of Neurology, Indiana University, Indianapolis, Indiana, USA.
Christoph LaskeEberhard Karls University of Tubingen, Tubingen, Germany.
Peter R SchofieldNeuroscience Research Australia and School of Medical Sciences, The University of New South Wales (UNSW) Sydney, Sydney, Australia.
Daniel S MarcusDepartment of Radiology, Washington University in Saint Louis, St. Louis, Missouri, USA.
John C MorrisDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Tammie L S BenzingerDepartment of Radiology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Randall J BatemanDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Beau M AncesDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Washington University in St. Louis · USColumbia University · USIndiana University – Purdue University Indianapolis · USUniversity College London · GBEmory University · USGerman Center for Neurodegenerative Diseases · DEMassachusetts General Hospital · USMayo Clinic · USMayo Clinic in Florida · USUniversity of Pittsburgh · USUniversity of Tübingen · DE

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Suzanne Elizabeth Schindler · 1985 to 2026
$69.5M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Andrea Denny · 2020 to 2026
$28.7M
Dominantly Inherited Alzheimer NetworkUF1AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2017
$21.6M
PET Imaging of Neuroinflammation in Genetic Alzheimer's DiseaseR01AG052550 · NIA · WASHINGTON UNIVERSITY · PI Beau M Ances, Tammie Lee Smith Benzinger · 2018 to 2026
$4.2M
FALLS: A MARKER OF PRECLINICAL ALZHEIMERS DISEASER01AG057680 · NIA · WASHINGTON UNIVERSITY · PI ANCES, BEAU M, STARK, SUSAN LYNN · 2018 to 2022
$3.4M
NEUROIMAGING AND NEUROBEHAVIORAL BASIS OF RISKY DECISION-MAKING IN ADOLESCENTSR01NR012907 · NINR · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2011 to 2015
$1.9M
THE EFFECTS OF AGE AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON BRAIN FUNCTIONR01NR012657 · NINR · WASHINGTON UNIVERSITY · PI ANCES, BEAU M · 2010 to 2014
$1.9M
Neuroimaging Markers of Emerging Dysfunction In Preclinical Alzheimer DiseaseK01AG053474 · NIA · WASHINGTON UNIVERSITY · PI GORDON, BRIAN ANDREW · 2017 to 2021
$623k
NCATS NIH HHS UL1 TR002345NIA NIH HHS K01 AG053474NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG052550NIA NIH HHS R01 AG057680NIA NIH HHS U19 AG032438NIA NIH HHS UF1 AG032438NINR NIH HHS R01 NR012657NINR NIH HHS R01 NR012907
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainCross-Sectional StudiesHumansMagnetic Resonance ImagingPositron-Emission TomographyAmyloid beta-PeptidesBiomarkers18F-fluorodeoxyglucose (FDG)amyloidautosomal dominant Alzheimer diseasecerebrospinal fluid (CSF)estimated years to onset (EYO)hippocampuspositron emission tomography (PET)resting-state functional connectivitytau

Identifiers

PMID33430685
PMCPMC8182476
OpenAlexW3119908925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.