Evidence map›Paper›PMID 33430521›Full record

ArticleViruses2021

Pan-Enterovirus Amplicon-Based High-Throughput Sequencing Detects the Complete Capsid of a EVA71 Genotype C1 Variant via Wastewater-Based Epidemiology in Arizona.

Temitope O C Faleye, Erin Driver, Devin Bowes, Sangeet Adhikari, Deborah Adams, Arvind Varsani, Rolf U Halden, Matthew Scotch

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Canine picornaviruses detected in wastewater in Arizona, USA 2019 and 2021.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Temitope O C FaleyeBiodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Erin DriverBiodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0001-9675-9764
Devin BowesBiodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Sangeet AdhikariBiodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Deborah AdamsBiodesign Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-7847-3508
Arvind VarsaniBiodesign Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0003-4111-2415
Rolf U HaldenBiodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Matthew ScotchBiodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0001-5100-9724

Funding

Bioinformatics Framework for Wastewater-based Surveillance of Infectious DiseasesU01LM013129 · NLM · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI HALDEN, ROLF U, SCOTCH, MATTHEW · 2020 to 2022
$3.3M
Bioinformatics Framework for Wastewater-based Surveillance of Infectious DiseasesR01LM013129 · NLM · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI HALDEN, ROLF U, SCOTCH, MATTHEW · 2019 to 2019
$395k
NIH HHS R01LM013129NLM NIH HHS U01 LM013129
6 · The paper itself

Abstract

We describe the complete capsid of a genotype C1-like Enterovirus A71 variant recovered from wastewater in a neighborhood in the greater Tempe, Arizona area (Southwest United States) in May 2020 using a pan-enterovirus amplicon-based high-throughput sequencing strategy. The variant seems to have been circulating for over two years, but its sequence has not been documented in that period. As the SARS-CoV-2 pandemic has resulted in changes in health-seeking behavior and overwhelmed pathogen diagnostics, our findings highlight the importance of wastewater-based epidemiology (WBE ) as an early warning system for virus surveillance.

Indexed as

Wastewater-Based Epidemiological MonitoringArizonaCapsidCapsid ProteinsEnterovirus A, HumanEnterovirus InfectionsHigh-Throughput Nucleotide SequencingHumansMolecular EpidemiologyPandemicsPhylogenyWastewaterCapsid ProteinsWastewaterArizonaEnterovirus Ahumanmolecular epidemiologypoliomyelitiswastewater

Identifiers

PMID33430521
PMCPMC7827028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.