ArticleInternational journal of molecular sciences2021
Post-Translational Modifications of Nitrate Reductases Autoregulates Nitric Oxide Biosynthesis in Arabidopsis.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Post-Translational Control of Nitrate Reductase Under Elevated COPlants (Basel, Switzerland) · 2026Review
- Functional divergence and symbiotic significance of nitrate reductase isoforms in Medicago truncatula.Plant physiology · 2026Article
- The Wheat Nitro-Proteome: Protein Nitration Profiles During Drought and Rehydration.Plants (Basel, Switzerland) · 2026Article
- Integration of NO and HPlant communications · 2026Review
- Peroxynitrite-mediated tyrosine nitration modulates β-1,3-glucanase activity and potato defense againstFrontiers in plant science · 2026Article
- Plant stress physiology under environmental emerging contaminant exposure: from molecular responses to phytoremediation applications.Frontiers in plant science · 2026Review
- NO and HInternational journal of molecular sciences · 2024Review
- Long-term conservation tillage with reduced nitrogen fertilization intensity can improve winter wheat health via positive plant-microorganism feedback in the rhizosphere.FEMS microbiology ecology · 2024Article
- The Arabidopsis thioredoxin TRXh5regulates the S-nitrosylation pattern of the TIRK receptor being both proteins essential in the modulation of defences to Tetranychus urticae.Redox biology · 2023Article
- Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants.Journal of experimental botany · 2023Article
- Exogenous Putrescine Modulates Nitrate Reductase-Dependent NO Production in Cucumber Seedlings Subjected to Salt Stress.Metabolites · 2023Article
- Bringing Nitric Oxide to the Molybdenum World-A Personal Perspective.Molecules (Basel, Switzerland) · 2023Review
- Multiple Ways of Nitric Oxide Production in Plants and Its Functional Activity under Abiotic Stress Conditions.International journal of molecular sciences · 2023Review
- Effects of nitrate and ammonium on assimilation of nitric oxide by Heterosigma akashiwo.Scientific reports · 2023Article
- Free Radicals Mediated Redox Signaling in Plant Stress Tolerance.Life (Basel, Switzerland) · 2023Review
- Functions of NO and HMethods in molecular biology (Clifton, N.J.) · 2023Article
- Signaling by reactive molecules and antioxidants in legume nodules.The New phytologist · 2022Review
- Nitrate-Nitrite-Nitric Oxide Pathway: A Mechanism of Hypoxia and Anoxia Tolerance in Plants.International journal of molecular sciences · 2022Review
- Bioactive Nitrosylated and NitratedMolecules (Basel, Switzerland) · 2022Article
- Protein Tyrosine Nitration in Plant Nitric Oxide Signaling.Frontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Nitric oxide (NO) is a regulator of growth, development, and stress responses in living organisms. Plant nitrate reductases (NR) catalyze the reduction of nitrate to nitrite or, alternatively, to NO. In plants, NO action and its targets remain incompletely understood, and the way NO regulates its own homeostasis remains to be elucidated. A significant transcriptome overlapping between NO-deficient mutant and NO-treated wild type plants suggests that NO could negatively regulate its biosynthesis. A significant increase in NO content was detected in transgenic plants overexpressing NR1 and NR2 proteins. In turn, NR protein and activity as well as NO content, decreased in wild-type plants exposed to a pulse of NO gas. Tag-aided immunopurification procedures followed by tandem mass spectrometry allowed identifying NO-triggered post-translational modifications (PTMs) and ubiquitylation sites in NRs. Nitration of tyrosine residues and S-nitrosation of cysteine residues affected key amino acids involved in binding the essential FAD and molybdenum cofactors. NO-related PTMs were accompanied by ubiquitylation of lysine residues flanking the nitration and S-nitrosation sites. NO-induced PTMs of NRs potentially inhibit their activities and promote their proteasome-mediated degradation. This auto-regulatory feedback loop may control nitrate assimilation to ammonium and nitrite-derived production of NO under complex environmental conditions.
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