Evidence map›Paper›PMID 33430299›Full record

ArticleBiomolecules2021

Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies.

Lúcio Ricardo Leite Diniz, Yunierkis Perez-Castillo, Hatem A Elshabrawy, Carlos da Silva Maia Bezerra Filho, Damião Pergentino de Sousa

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

  1. Lipophilic Substances of the Leaves and Inflorescences ofMolecules (Basel, Switzerland) · 2025
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  5. In vivo evaluation of the antiretroviral activity of Melia azedarach against small ruminant lentiviruses in goat colostrum and milk.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Lúcio Ricardo Leite DinizCollege of Nordeste da Bahia, Coronel João Sá 48590-000, Brazil.
Yunierkis Perez-CastilloBio-Cheminformatics Research Group and Escuela de Ciencias Físicas y Matemáticas, Universidad de Las Américas, Quito 170125, Ecuador.ORCID 0000-0002-3710-0035
Hatem A ElshabrawyDepartment of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA.
Carlos da Silva Maia Bezerra FilhoDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil.ORCID 0000-0003-0628-5783
Damião Pergentino de SousaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil.ORCID 0000-0002-7180-4896
Universidade Federal da Paraíba · BRSam Houston State University · USUniversidad de Las Américas · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus; the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Millions of cases and deaths to date have resulted in a global challenge for healthcare systems. COVID-19 has a high mortality rate, especially in elderly individuals with pre-existing chronic comorbidities. There are currently no effective therapeutic approaches for the prevention and treatment of COVID-19. Therefore, the identification of effective therapeutics is a necessity. Terpenes are the largest class of natural products that could serve as a source of new drugs or as prototypes for the development of effective pharmacotherapeutic agents. In the present study, we discuss the antiviral activity of these natural products and we perform simulations against the M

Indexed as

Drug DiscoveryAntiviral AgentsCoronavirus 3C ProteasesCOVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationProtease InhibitorsSARS-CoV-2Terpenes3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesProtease InhibitorsTerpenesCOVID-19MERS-CoVMiddle East Respiratory Syndrome Virusnatural productsplantssaponinsSARS-CoVSARS-CoV-2terpenoidviruses

Identifiers

PMID33430299
PMCPMC7825698
OpenAlexW3121112951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.