ArticlePharmaceutics2021
CPE-DB: An Open Database of Chemical Penetration Enhancers.
Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enhancing Dermal Absorption of Cosmeceuticals: Innovations and Techniques for Targeted Skin Delivery.Journal of cosmetic dermatology · 2025Pooled it
- Microdermabrasion with Calcium Hydrogen Phosphate for Enhancing Skin Permeation of Lidocaine-tetracaine Eutectic Microemulsion Gel.Pharmaceutical research · 2026Article
- Progress in peptide and protein therapeutics: Challenges and strategies.Acta pharmaceutica Sinica. B · 2025Review
- Skin penetration enhancers: Mechanistic understanding and their selection for formulation and design.Drug delivery and translational research · 2025Review
- Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation.Pharmaceutics · 2025Review
- An Overview of Film-Forming Emulsions for Dermal and Transdermal Drug Delivery.AAPS PharmSciTech · 2024Review
- Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis.Acta pharmaceutica Sinica. B · 2023Review
- Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System.Pharmaceutics · 2023Review
- Natural Ingredients of Transdermal Drug Delivery Systems as Permeation Enhancers of Active Substances through theMolecular pharmaceutics · 2023Review
- Computational methods for identifying enhancer-promoter interactions.Quantitative biology (Beijing, China) · 2023Review
- Transdermal delivery for gene therapy.Drug delivery and translational research · 2022Review
- The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs.Polymers · 2022Review
- Mucosal Delivery of Cannabidiol: Influence of Vehicles and Enhancers.Pharmaceutics · 2022Article
- Molecular perspective of efficiency and safety problems of chemical enhancers: bottlenecks and recent advances.Drug delivery and translational research · 2022Review
- Application of traditional Chinese medicine in film drug delivery system.Frontiers in pharmacology · 2022Review
- The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years.International journal of molecular sciences · 2021Review
- Formulation and evaluation of transdermal nanogel for delivery of artemether.Drug delivery and translational research · 2021Article
- In Vitro Skin Permeation of Idebenone from Lipid Nanoparticles Containing Chemical Penetration Enhancers.Pharmaceutics · 2021Article
- Synergistic Effect of Chemical Penetration Enhancers on Lidocaine Permeability Revealed by Coarse-Grained Molecular Dynamics Simulations.Membranes · 2021Article
- Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery.Membranes · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The cutaneous delivery route currently accounts for almost 10% of all administered drugs and it is becoming more common. Chemical penetration enhancers (CPEs) increase the transport of drugs across skin layers by different mechanisms that depend on the chemical nature of the penetration enhancers. In our work, we created a chemical penetration enhancer database (CPE-DB) that is, to the best of our knowledge, the first CPE database. We collected information about known enhancers and their derivatives in a single database, and classified and characterized their molecular diversity in terms of scaffold content, key chemical moieties, molecular descriptors, etc. CPE-DB can be used for virtual screening and similarity search to identify new potent and safe enhancers, building quantitative structure-activity relationship (QSAR) and quantitative structure-property relationship (QSPR) models, and other machine-learning (ML) applications for the prediction of biological activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.