Trial reportInternational journal of environmental research and public health2021
Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study-A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline.
Trial report in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.Social psychiatry and psychiatric epidemiology · 2026Trial
- Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study.NeuroImage. Clinical · 2025Trial
- Dietary changes following a lifestyle-based intervention for dementia risk reduction - results from the AgeWell.de study.European journal of nutrition · 2024Trial
- Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- Quality of life in a high-risk group of elderly primary care patients: characteristics and potential for improvement.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Trial
- Adherence to a lifestyle intervention - just a question of self-efficacy? Analysis of the AgeWell.de-intervention against cognitive decline.Alzheimer's research & therapy · 2024Trial
- A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- [Modifiable risk and protective factors for dementia: an overview of established and emerging evidence].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Review
- Evaluating MRI correlates of lifestyle-based dementia risk reduction: Results from the AgeWell.de imaging study.Journal of Alzheimer's disease : JAD · 2026Article
- Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study.BMC primary care · 2025Article
- Factors associated with a healthy diet and willingness to change dietary behavior in older adults at increased risk of dementia.Journal of Alzheimer's disease : JAD · 2025Article
- Article
- CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process.Frontiers in aging neuroscience · 2025Article
- General practitioners' perspectives on lifestyle interventions for cognitive preservation in dementia prevention.BMC primary care · 2024Article
- Social participation and cognitive activities as explanation factor for the association between income and self-rated health for older adults.Frontiers in public health · 2024Article
- Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People-A Cross-Sectional Analysis from the AgeWell.de-Study.Journal of clinical medicine · 2023Article
- [Prevention and health promotion in dementia: motivation for change within preventive interventions-Empirical results].Der Nervenarzt · 2023Review
- [Public mental health: Core component or side issue of public health?]Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Depression and Anxiety in Old Age during the COVID-19 Pandemic: A Comparative Study of Individuals at Cardiovascular Risk and the General Population.International journal of environmental research and public health · 2023Article
- COVID-19 government measures and their impact on mental health: a cross-sectional study of older primary care patients in Germany.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 2 countries.
Funding
Abstract
Targeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the first large-scale initiative investigating the effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate the recruitment process and baseline characteristics of the AgeWell.de participants to gain an understanding of the at-risk population and who engages in the intervention. General practitioners across five study sites recruited participants (aged 60-77 years, Cardiovascular Risk Factors, Aging, and Incidence of Dementia/CAIDE dementia risk score ≥ 9). Structured face-to-face interviews were conducted with eligible participants, including neuropsychological assessments. We analyzed group differences between (1) eligible vs. non-eligible participants, (2) participants vs. non-participants, and (3) between intervention groups. Of 1176 eligible participants, 146 (12.5%) dropped out before baseline; the study population was thus 1030 individuals. Non-participants did not differ from participants in key sociodemographic factors and dementia risk. Study participants were M = 69.0 (SD = 4.9) years old, and 52.1% were women. The average Montreal Cognitive Assessment/MoCA score was 24.5 (SD = 3.1), indicating a rather mildly cognitively impaired study population; however, 39.4% scored ≥ 26, thus being cognitively unimpaired. The bandwidth of cognitive states bears the interesting potential for differential trial outcome analyses. However, trial conduction is impacted by the COVID-19 pandemic, requiring adjustments to the study protocol with yet unclear methodological consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.