Evidence map›Paper›PMID 33430160›Full record

ArticleInternational journal of molecular sciences2021

MALDI TOF Mass Spectrometry Imaging of Blood Smear: Method Development and Evaluation.

Željko Debeljak, Ann-Christin Niehoff, Ana Bandjak, Dario Mandić, Bojana Bošnjak, Marija Heffer, Stefan Mrđenović, Ivana Marković, Milorad Zjalić, Vatroslav Šerić

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Željko DebeljakClinical Institute of Laboratory Diagnostics, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.
Ann-Christin NiehoffEuropean Innovation Center, Shimadzu Europa GmbH, Albert-Hahn-Straße 6-10, 47269 Duisburg, Germany.
Ana BandjakClinical Institute of Laboratory Diagnostics, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.
Dario MandićClinical Institute of Laboratory Diagnostics, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.ORCID 0000-0002-3792-4384
Bojana BošnjakClinical Institute of Transfusion Medicine, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.
Marija HefferDepartment of Medical Biology and Genetics, Faculty of Medicine, JJ Strossmayer University of Osijek, J. Huttlera 4, 31 000 Osijek, Croatia.ORCID 0000-0001-6770-7359
Stefan MrđenovićDepartment of Hematology, Internal Medicine Clinic, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.
Ivana MarkovićClinical Institute of Laboratory Diagnostics, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.
Milorad ZjalićDepartment of Medical Biology and Genetics, Faculty of Medicine, JJ Strossmayer University of Osijek, J. Huttlera 4, 31 000 Osijek, Croatia.
Vatroslav ŠerićClinical Institute of Laboratory Diagnostics, Osijek University Hospital, J. Huttlera 4, 31 000 Osijek, Croatia.

Funding

European Regional Fund and Croatian Ministry of Science Infrastructural Project grant KK.01.1.1.02.0015
6 · The paper itself

Abstract

The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears coming from healthy male donors. Different blood plasma removal, matrix deposition, and instrumental settings were evaluated using the negative and positive ionization modes while agreement between the light microscopy images and the lateral distributions of cellular marker compounds served as the MSI quality indicator. Red and white blood cells chemical composition was analyzed using the differential

Indexed as

Diagnostic Tests, RoutineAdultBiomarkersErythrocytesHealthy VolunteersHumansLeukocytesMaleSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationYoung AdultBiomarkersblood smearMALDI TOFmass spectrometry imagingmethod development

Identifiers

PMID33430160
PMCPMC7827909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.