Evidence map›Paper›PMID 33430133›Full record

ReviewInternational journal of molecular sciences2021

Editing and Chemical Modifications on Non-Coding RNAs in Cancer: A New Tale with Clinical Significance.

Ligia I Torsin, George E D Petrescu, Alexandru A Sabo, Baoqing Chen, Felix M Brehar, Mihnea P Dragomir, George A Calin

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. RBPs: an RNA editor's choice.Frontiers in molecular biosciences · 2024
    Review
  8. Identification of mScientific reports · 2023
    Article
  9. Review
  10. MDiscover oncology · 2023
    Article
  11. Article
  12. Article
  13. Epigenetic reprogramming in cancer: From diagnosis to treatment.Frontiers in cell and developmental biology · 2023
    Review
  14. Review
  15. Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications.International journal of molecular sciences · 2022
    Review
  16. Tumor-Suppressive and Oncogenic Roles of microRNA-149-5p in Human Cancers.International journal of molecular sciences · 2022
    Review
  17. Review
  18. Article
  19. ADAR1-Mediated RNA Editing and Its Role in Cancer.Frontiers in cell and developmental biology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Ligia I TorsinDepartment of Anesthesiology and Critical Care, Elias Clinical Emergency Hospital, 011461 Bucharest, Romania.ORCID 0000-0003-3950-1382
George E D PetrescuDepartment of Neurosurgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0003-2651-3608
Alexandru A SaboZentrum für Kinder, Jugend und Frauenmedizin, Pediatrics 2 (General and Special Pediatrics), Klinikum Stuttgart, Olgahospital, 70174 Stuttgart, Germany.
Baoqing ChenDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
Felix M BreharDepartment of Neurosurgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Mihnea P DragomirInstitute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
George A CalinDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-5550-3516
Carol Davila University of Medicine and Pharmacy · ROCharité - Universitätsmedizin Berlin · DEClinical Emergency Hospital Bucharest · ROOlgahospital · DESun Yat-sen University · CNThe University of Texas MD Anderson Cancer Center · US

Funding

Protein-coding and non-coding RNA biomarkers for early detection of CLLR01CA182905 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABRUZZO, LYNNE V., CALIN, GEORGE A. · 2014 to 2018
$2.9M
miR-155 targeted therapeutics for precision medicine in lung cancerR01CA222007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., CRISTINI, VITTORIO · 2018 to 2022
$2.6M
Viral miRs and cellular miRs in sepsisR01GM122775 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., LUPU, FLOREA · 2018 to 2020
$1.1M
Center for Strategic Scientific Initiatives, National Cancer Institute 1R01 CA182905-01Center for Strategic Scientific Initiatives, National Cancer Institute 1R01CA222007-01A1NIGMS NIH HHS 1R01GM122775-01NIH HHS UH3TR00943-01
6 · The paper itself

Abstract

Currently, for seemingly every type of cancer, dysregulated levels of non-coding RNAs (ncRNAs) are reported and non-coding transcripts are expected to be the next class of diagnostic and therapeutic tools in oncology. Recently, alterations to the ncRNAs transcriptome have emerged as a novel hallmark of cancer. Historically, ncRNAs were characterized mainly as regulators and little attention was paid to the mechanisms that regulate them. The role of modifications, which can control the function of ncRNAs post-transcriptionally, only recently began to emerge. Typically, these modifications can be divided into reversible (i.e., chemical modifications: m

Indexed as

CarcinogenesisHumansNeoplasmsRNA EditingRNA, UntranslatedTranscriptomeRNA, Untranslatedcancercircular RNA.long non-coding RNAmicroRNAnon-coding RNARNA chemical modificationsRNA editing

Identifiers

PMID33430133
PMCPMC7827606
OpenAlexW3118861982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.