Evidence map›Paper›PMID 33430073›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Evaluation of Cysteine Metabolism in the Rat Liver and Kidney Following Intravenous Cocaine Administration and Abstinence.

Danuta Kowalczyk-Pachel, Małgorzata Iciek, Anna Bilska-Wilkosz, Magdalena Górny, Joanna Jastrzębska, Kinga Kamińska, Paulina Dudzik, Małgorzata Filip, Elżbieta Lorenc-Koci

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Danuta Kowalczyk-PachelThe Chair of Medical Biochemistry, Medical College, Jagiellonian University, 7, Kopernika St., PL-31-034 Kraków, Poland.
Małgorzata IciekThe Chair of Medical Biochemistry, Medical College, Jagiellonian University, 7, Kopernika St., PL-31-034 Kraków, Poland.
Anna Bilska-WilkoszThe Chair of Medical Biochemistry, Medical College, Jagiellonian University, 7, Kopernika St., PL-31-034 Kraków, Poland.ORCID 0000-0001-9066-6292
Magdalena GórnyThe Chair of Medical Biochemistry, Medical College, Jagiellonian University, 7, Kopernika St., PL-31-034 Kraków, Poland.ORCID 0000-0002-6393-9977
Joanna JastrzębskaMaj Institute of Pharmacology, Polish Academy of Sciences, 12, Smętna St., PL-31-343 Kraków, Poland.
Kinga KamińskaMaj Institute of Pharmacology, Polish Academy of Sciences, 12, Smętna St., PL-31-343 Kraków, Poland.
Paulina DudzikThe Chair of Medical Biochemistry, Medical College, Jagiellonian University, 7, Kopernika St., PL-31-034 Kraków, Poland.
Małgorzata FilipMaj Institute of Pharmacology, Polish Academy of Sciences, 12, Smętna St., PL-31-343 Kraków, Poland.
Elżbieta Lorenc-KociMaj Institute of Pharmacology, Polish Academy of Sciences, 12, Smętna St., PL-31-343 Kraków, Poland.ORCID 0000-0002-9970-8548
Jagiellonian University · PLMaj Institute of Pharmacology · PL

Funding

Statutory Funds of the Maj Institute of Pharmacology Polish Academy of Sciences no grant
6 · The paper itself

Abstract

Many toxic effects of cocaine are attributed to reactive oxygen species (ROS) generated during its metabolism. Recently, it has been suggested that the biological action of ROS is often confused with endogenously generated reactive sulfur species (RSS). The aim of this study was to evaluate the impact of cocaine on thiols and RSS in the rat liver and kidney in the drug self-administration (SA) paradigm and the cocaine yoked delivery model (YC) followed by drug abstinence with extinction training. The level of thiols as well as RSS formed during anaerobic metabolism of cysteine and sulfate were assayed. In addition, the activity of enzymes involved in RSS formation and glutathione metabolism were determined. In the liver, following direct cocaine administration (SA and YC), the RSS levels decreased, while in the kidneys, cocaine increased the RSS contents in both groups. These changes were maintained in these tissues during drug abstinence. The level of sulfates was changed by cocaine only in the liver. In the kidney, cocaine shifted cysteine metabolism towards an anaerobic pathway. Our study demonstrates for the first time the changes in cysteine metabolism and thiol levels in the liver and kidney of rats after cocaine self-administration and abstinence.

Indexed as

cocainereactive sulfur speciesself-administrationthiolsyoked procedure

Identifiers

PMID33430073
PMCPMC7827093
OpenAlexW3119341205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.