Evidence map›Paper›PMID 33430016›Full record

ArticleInternational journal of molecular sciences2021

Assessment of Physico-Chemical and Toxicological Properties of Commercial 2D Boron Nitride Nanopowder and Nanoplatelets.

Brixhilda Domi, Kapil Bhorkar, Carlos Rumbo, Labrini Sygellou, Spyros N Yannopoulos, Rocio Barros, Roberto Quesada, Juan Antonio Tamayo-Ramos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Crossing the Borders of Nanomedicine.International journal of molecular sciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brixhilda DomiInternational Research Centre in Critical Raw Materials (ICCRAM), Universidad de Burgos, Plaza Misael Banuelos s/n, 09001 Burgos, Spain.
Kapil BhorkarFoundation for Research and Technology Hellas-Institute of Chemical Engineering Sciences (FORTH/ICE-HT), P.O. Box 1414, GR-26504 Rio-Patras, Greece.ORCID 0000-0001-8062-8639
Carlos RumboInternational Research Centre in Critical Raw Materials (ICCRAM), Universidad de Burgos, Plaza Misael Banuelos s/n, 09001 Burgos, Spain.
Labrini SygellouFoundation for Research and Technology Hellas-Institute of Chemical Engineering Sciences (FORTH/ICE-HT), P.O. Box 1414, GR-26504 Rio-Patras, Greece.
Spyros N YannopoulosFoundation for Research and Technology Hellas-Institute of Chemical Engineering Sciences (FORTH/ICE-HT), P.O. Box 1414, GR-26504 Rio-Patras, Greece.ORCID 0000-0001-6684-3172
Rocio BarrosInternational Research Centre in Critical Raw Materials (ICCRAM), Universidad de Burgos, Plaza Misael Banuelos s/n, 09001 Burgos, Spain.
Roberto QuesadaDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, 09001 Burgos, Spain.ORCID 0000-0003-2764-7157
Juan Antonio Tamayo-RamosInternational Research Centre in Critical Raw Materials (ICCRAM), Universidad de Burgos, Plaza Misael Banuelos s/n, 09001 Burgos, Spain.ORCID 0000-0002-7071-002X

Funding

H2020-MSCA-ITN 721642
6 · The paper itself

Abstract

Boron nitride (BN) nanomaterials have been increasingly explored for potential applications in chemistry and biology fields (e.g., biomedical, pharmaceutical, and energy industries) due to their unique physico-chemical properties. However, their safe utilization requires a profound knowledge on their potential toxicological and environmental impact. To date, BN nanoparticles have been considered to have a high biocompatibility degree, but in some cases, contradictory results on their potential toxicity have been reported. Therefore, in the present study, we assessed two commercial 2D BN samples, namely BN-nanopowder (BN-PW) and BN-nanoplatelet (BN-PL), with the objective to identify whether distinct physico-chemical features may have an influence on the biological responses of exposed cellular models. Morphological, structural, and composition analyses showed that the most remarkable difference between both commercial samples was the diameter of their disk-like shape, which was of 200-300 nm for BN-PL and 100-150 nm for BN-PW. Their potential toxicity was investigated using adenocarcinomic human alveolar basal epithelial cells (A549 cells) and the unicellular fungus

Indexed as

Blood PlateletsBoron CompoundsHumansNanostructuresOxidative StressReactive Oxygen SpeciesBoron Compoundsboron nitrideReactive Oxygen Species2D boron nitridecell viabilityeukaryotic modelnanotoxicityoxidative stress

Identifiers

PMID33430016
PMCPMC7827597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.