Evidence map›Paper›PMID 33429915›Full record

ArticleSensors (Basel, Switzerland)2021

Rapid SARS-CoV-2 Detection Using Electrochemical Immunosensor.

Biljana Mojsoska, Sylvester Larsen, Dorte Aalund Olsen, Jonna Skov Madsen, Ivan Brandslund, Fatima AlZahra'a Alatraktchi

Abstract readValidation Study
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. ACS pharmacology & translational science · 2025
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  15. Two-Dimensional (2D) materials in the detection of SARS-CoV-2.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2023
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Biljana MojsoskaDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark.ORCID 0000-0001-5901-7753
Sylvester LarsenDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark.ORCID 0000-0002-6631-3056
Dorte Aalund OlsenDepartment of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.ORCID 0000-0003-2589-738X
Jonna Skov MadsenDepartment of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.ORCID 0000-0001-6668-4714
Ivan BrandslundDepartment of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.
Fatima AlZahra'a AlatraktchiDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark.ORCID 0000-0003-3297-2560

Funding

Innovationsfonden 0208-00030A
6 · The paper itself

Abstract

The outbreak of the coronavirus disease (COVID-19) pandemic caused by the novel coronavirus (SARS-CoV-2) has been declared an international public health crisis. It is essential to develop diagnostic tests that can quickly identify infected individuals to limit the spread of the virus and assign treatment options. Herein, we report a proof-of-concept label-free electrochemical immunoassay for the rapid detection of SARS-CoV-2 virus via the spike surface protein. The assay consists of a graphene working electrode functionalized with anti-spike antibodies. The concept of the immunosensor is to detect the signal perturbation obtained from ferri/ferrocyanide measurements after binding of the antigen during 45 min of incubation with a sample. The absolute change in the [Fe(CN)

Indexed as

Point-of-Care TestingAntigens, ViralBiosensing TechniquesCOVID-19COVID-19 TestingDielectric SpectroscopyElectrochemical TechniquesEnzyme-Linked Immunosorbent AssayEquipment DesignGraphiteHumansLimit of DetectionPandemicsProof of Concept StudyProtein SubunitsSARS-CoV-2Antigens, ViralGraphiteProtein SubunitsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-22019-nCoVbiosensorcoronaCOVID-19diagnosticselectrochemical sensingimmunosensorSARS-CoV-2spike proteinvoltammetry

Identifiers

PMID33429915
PMCPMC7827295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.