Evidence map›Paper›PMID 33429895›Full record

ArticleBiomedicines2021

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.

Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Yanyan Wang, Toshikuni Sasaoka, Luc Bousset, Ronald Melki, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Ichiro KawahataDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0002-5916-7847
Tomoki SekimoriDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Haoyang WangDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yanyan WangDepartment of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, 3900 University Blvd, Tyler, TX 75799, USA.
Toshikuni SasaokaDepartment of Comparative and Experimental Medicine, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Luc BoussetLaboratory of Neurodegenerative Diseases, Institut François Jacob (MIRcen), Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), 18 Route du Panorama, 92265 Fontenay-aux-Roses, France.
Ronald MelkiLaboratory of Neurodegenerative Diseases, Institut François Jacob (MIRcen), Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), 18 Route du Panorama, 92265 Fontenay-aux-Roses, France.
Tomohiro MizobataDepartment of Chemistry and Biotechnology, Graduate School of Engineering Tottori University, Tottori 680-8550, Japan.ORCID 0000-0002-7808-2099
Yasushi KawataDepartment of Chemistry and Biotechnology, Graduate School of Engineering Tottori University, Tottori 680-8550, Japan.ORCID 0000-0002-2744-1506
Kohji FukunagaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Tohoku University · JPCentre National de la Recherche Scientifique · FRTottori University · JPNiigata University · JPThe University of Texas at Tyler · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson's disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate in dopaminergic neurons. FABP3 is abundant in dopaminergic neurons and interacts with dopamine D2 receptors, specifically the long type (D

Indexed as

dopamine D2L receptordopaminergic neuronsfatty acid-binding protein 3 (FABP3)Parkinson’s diseasesynucleinopathyα-synuclein

Identifiers

PMID33429895
PMCPMC7826971
OpenAlexW3120694543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.