Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation.

Jiayu Sun, Jie Li, Hongbao Sun, Chunling Li, Haoxing Wu

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiayu SunDepartment of Radiology, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu 610041, China.

Jie LiDepartment of Radiology, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu 610041, China.

Hongbao SunDepartment of Radiology, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu 610041, China.

Chunling LiDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.

Haoxing WuDepartment of Radiology, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu 610041, China.

Funding

1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University ZYYC08004Key Research and Development Projects in Sichuan Province 2020YFS0123National Natural Science Foundation 21801178

6 · The paper itself

Abstract

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile to generate stable substrates suitable for bioorthogonal tetrazine ligation.

Indexed as

Cycloaddition ReactionHeterocyclic CompoundsHeterocyclic Compoundsbioorthogonal chemistryconcise synthesisfunctionalized cyclobutene analoguestetrazine ligation

Identifiers

PMID33429851

DOI10.3390/molecules26020276

PMCPMC7827859

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.