Evidence map›Paper›PMID 33429739›Full record

ArticleMedicine2021

Identification of an IGF1 mutation (c.15+3G>A) in familial osteonecrosis of the femoral head: A case report.

Qi Xu, Da Song, Zhensong Wu, Bo Fu, Juan Zheng, Rongrong Li, Han Yin, Shuangfeng Chen, Dawei Wang

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qi XuDepartment of Joint Surgery, Liaocheng People's Hospital, Liaocheng.
Da SongDepartment of Joint Surgery, Liaocheng People's Hospital, Liaocheng.
Zhensong WuDepartment of Joint Surgery, Zaozhuang Municipal Hospital, Zaozhuang.
Bo FuDepartment of Central Laboratory.
Juan ZhengDepartment of Joint Laboratory for Translational Medicine Research, Liaocheng People's Hospital, Liaocheng, China.
Rongrong LiDepartment of Joint Laboratory for Translational Medicine Research, Liaocheng People's Hospital, Liaocheng, China.
Han YinDepartment of Joint Surgery, Liaocheng People's Hospital, Liaocheng.
Shuangfeng ChenDepartment of Central Laboratory.
Dawei WangDepartment of Joint Surgery, Liaocheng People's Hospital, Liaocheng.
Liaocheng People's Hospital · CNZaozhuang Municipal Hospital · CN

Funding

China Postdoctoral Science Foundation 2017M612290National Nature Science Foundation of China 81702884
6 · The paper itself

Abstract

rationaleOsteonecrosis of the femoral head is a common orthopedic disease. Some studies have shown that osteonecrosis of the femoral head is related to susceptibility genes, but there are few reports of familial osteonecrosis of the femoral head. Here, we reported two first-degree relatives with osteonecrosis of the femoral head. PATIENT CONCERNS: A 27-year-old man with bilateral hip pain was diagnosed with osteonecrosis of the femoral head. The patient's mother also had a history of this disease. DIAGNOSES: Whole exome sequencing revealed the same mutation (c.15+3G>A) in the insulin-like growth factor 1 (IGF1) gene of the proband and his mother but not in his elder sister.

interventionsThe patient underwent bilateral total hip arthroplast. OUTCOMES: The patient recovered well, and was discharged. LESSONS: We found a heterozygous mutation (c.15+3G>A) in IGF1 in this family, which could be related to osteonecrosis of the femoral head. Early genetic counseling and gene locus detection could, thus, prove helpful for early diagnosis of osteonecrosis of the femoral head.

Indexed as

AdultArthroplasty, Replacement, HipFemur HeadHumansInsulin-Like Growth Factor IMaleOsteonecrosisIGF1 protein, humanInsulin-Like Growth Factor I

Identifiers

PMID33429739
PMCPMC7793511
OpenAlexW3119627560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.