ArticleACS biomaterials science & engineering2015
Multifunctional Self-Assembled Films for Rapid Hemostat and Sustained Anti-infective Delivery.
Article in ACS biomaterials science & engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Biobased adhesive hydrogels for wound management and tissue repair: From materials to advanced applications.APL bioengineering · 2026Review
- Silk Fibroin/Tannin/ZnO Nanocomposite Hydrogel with Hemostatic Activities.Gels (Basel, Switzerland) · 2022Article
- Biomaterials for Hemostasis.Annual review of biomedical engineering · 2022Review
- Recent advances in biopolymer-based hemostatic materials.Regenerative biomaterials · 2022Review
- Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds.Materials today. Bio · 2021Article
- Berberine-Coated Biomimetic Composite Microspheres for Simultaneously Hemostatic and Antibacterial Performance.Polymers · 2021Article
- Biomass-Derived Multilayer-Structured Microparticles for Accelerated Hemostasis and Bone Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Sustained Release Technology and Its Application in Environmental Remediation: A Review.International journal of environmental research and public health · 2019Review
- Macrophages with cellular backpacks for targeted drug delivery to the brain.Biomaterials · 2017Article
- Using biomaterials to rewire the process of wound repair.Biomaterials science · 2017Review
- Biosynthetic Polymers as Functional Materials.Macromolecules · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Uncontrolled bleeding and infection are the major causes of death and morbidity from traumatic wounds during military conflicts, disasters, and accidents. Because immediate treatment is critical to survival, it is desirable to have a lightweight and rapidly applicable bandage-one capable of delivering a hemostat that can quickly resolve bleeding while addressing infection over short and longer time frames. It is challenging to design thin film coatings capable of multidrug release, particularly when the drugs are quite different in nature (biologic versus small molecule, charged versus neutral) and the desired release profiles are different for each drug. Herein we have adopted a layer-by-layer film assembly technique to create a linear combination of two independently functional films capable of rapidly releasing thrombin within minutes while sustaining vancomycin elution for more than 24 h. By conjugating vancomycin to a hydrolytically degradable polyacid, poly(β-L-malic acid), we were able to create a robust thin film with loading and release kinetics that remain unaffected by the additional deposition of a thrombin-based film, demonstrating the possibility for future multitherapeutic films with independently tunable release kinetics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.