ArticleCerebral cortex (New York, N.Y. : 1991)2021
Pubertal Testosterone and the Structure of the Cerebral Cortex in Young Men.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Structural, Functional, and Metabolic Brain Differences as a Function of Gender Identity or Sexual Orientation: A Systematic Review of the Human Neuroimaging Literature.Archives of sexual behavior · 2021Pooled it
- Influence of sex and systemic lupus erythematosus disease status on cerebral cortex structure.Lupus science & medicine · 2026Trial
- Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Within-person biological mechanisms of mood variability in childhood and adolescence.Human brain mapping · 2024Article
- The Role of Puberty and Sex on Brain Structure in Adolescents With Anxiety Following Concussion.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology.Molecular psychiatry · 2023Article
- Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality.Biology of sex differences · 2022Article
- The impact of genetic risk for Alzheimer's disease on the structural brain networks of young adults.Frontiers in neuroscience · 2022Article
- A Practical Guide to SparseFrontiers in neuroscience · 2021Article
- The Inverted U: Exploring the Interconnectedness of Movement and Cognitive Function Across the Lifespan.Wiley interdisciplinary reviews. Cognitive scienceReview
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Adolescence is a period of brain maturation that may involve a second wave of organizational effects of sex steroids on the brain. Rodent studies suggest that, overall, organizational effects of gonadal steroid hormones decrease from the prenatal/perinatal period to adulthood. Here we used multimodal magnetic resonance imaging to investigate whether 1) testosterone exposure during adolescence (9-17 years) correlates with the structure of cerebral cortex in young men (n = 216, 19 years of age); 2) this relationship is modulated by the timing of testosterone surge during puberty. Our results showed that pubertal testosterone correlates with structural properties of the cerebral cortex, as captured by principal component analysis of T1 and T2 relaxation times, myelin water fraction, magnetization transfer ratio, fractional anisotropy and mean diffusivity. Many of the correlations between pubertal testosterone and the cortical structure were stronger in individuals with earlier (vs. later) testosterone surge. We also demonstrated that the strength of the relationship between pubertal testosterone and cortical structure across the cerebral cortex varies as a function of inter-regional profiles of gene expression specific to dendrites, axonal cytoskeleton, and myelin. This finding suggests that the cellular substrate underlying the relationships between pubertal testosterone and cerebral cortex involves both dendritic arbor and axon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.